紫外线辐射是角质细胞癌的主要风险因素。由于发病率的增加，必须探索新的光保护方法。口服摄入光保护化合物呈现出一种有希望的替代方法。植物化学化合物如异橙皮苷甲基茚花酮、邻苯三酚和杨梅酸因其抗氧化特性特别受到关注。我们的主要目标是评估口服植物化学物质对光致癌作用的影响，以肿瘤发生时间为主要终点。共有125只无毛C3.Cg-Hrhr/TifBom Tac小鼠被随机分配到接受饮用水中补充100 mg/kg异橙皮苷甲基茚花酮、邻苯三酚或杨梅酸、作为阳性对照的600 mg/kg烟酰胺或无补充物。小鼠每周三次受到3.5个标准红斑剂量的照射，以诱导光致癌作用。补充植物化合物邻苯三酚和杨梅酸以及烟酰胺可以延迟肿瘤的发生时间，分别从中位数140天延迟到151天（p = 0.036）、157天（p = 0.02）和178天（p = 2.7·10-5）。邻苯三酚和烟酰胺的补充物减少了肿瘤数量。烟酰胺增加了紫外线诱导的色素沉着并减少了水肿形成，而邻苯三酚的补充物则减少了表皮厚度。这些结果表明，口服摄入邻苯三酚和杨梅酸可以保护无毛小鼠免受光致癌作用的影响，但程度不及烟酰胺。版权所有© 2023 The Authors. 由Elsevier B.V.出版。保留所有权利。

Ultraviolet radiation is the primary risk factor for keratinocyte carcinoma. Because of increasing incidence rates, new methods of photoprotection must be explored. Oral supplementation with photoprotective compounds presents a promising alternative. Phytochemical compounds like hesperidin methyl chalcone, phloroglucinol, and syringic acid are particularly of interest because of their antioxidant properties. Our primary outcome was to evaluate the effects of oral phytochemicals on photocarcinogenesis with time until tumour onset as the primary endpoint. A total of 125 hairless C3.Cg-Hrhr/TifBom Tac mice were randomised to receive tap water supplemented with either 100 mg/kg hesperidin methyl chalcone, phloroglucinol, or syringic acid, 600 mg/kg nicotinamide as a positive control, or no supplementation. The mice were irradiated with 3.5 standard erythema doses thrice weekly to induce photocarcinogenesis. Supplementation with the phytochemicals phloroglucinol and syringic acid and nicotinamide delayed tumour onset from a median of 140 days to 151 (p = 0.036), 157 days (p = 0.02), and 178 (p = 2.7·10-5), respectively. Phloroglucinol and nicotinamide supplementation reduced tumour number. Nicotinamide increased UV-induced pigmentation and reduced oedema formation, while phloroglucinol supplementation reduced epidermal thickness. These results indicate that oral supplementation with phloroglucinol and syringic acid protects against photocarcinogenesis in hairless mice, but not to the same extent as nicotinamide.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.