人类癌症非编码RNA介导的糖酵解调控的分子特征。
Molecular profile of non-coding RNA-mediated glycolysis control in human cancers.
发表日期：2023 Jul 23
作者：
Sepideh Mirzaei, Bijan Ranjbar, Saeed Hesami Tackallou
来源：
Epigenetics & Chromatin
摘要：
糖酵解是癌症的一个常见特征，它负责提供足够的能量以确保生长。抑制糖酵解有利于减少肿瘤的生长。糖酵解在癌症中的刺激/抑制受非编码RNA（ncRNA）的严密调控。ncRNA对糖酵解的调控能够影响肿瘤的增殖和治疗反应。miRNA能够失活糖酵解酶并抑制信号网络，从而诱导糖酵解的进行。通过调控糖酵解，miRNA能够影响治疗反应。lncRNA和circRNA遵循相同的途径，通过靶向糖酵解，它们影响肿瘤的进展和治疗反应。值得注意的是，lncRNA和circRNA在调控肿瘤细胞中的糖酵解机制时与miRNA竞争。此外，ncRNA介导的糖酵解机制调控可以影响到身体器官的转移。调控糖酵解的ncRNA在癌症患者中是可靠的生物标志物，而更重要的是，由于存在于体液中，外泌体中的ncRNA是非侵入性的生物标志物。版权所有 © 2023 Elsevier GmbH。保留所有权利。
The glycolysis is a common characteristic of cancer and it is responsible for providing enough energy to ensure growth. The glycolysis suppression is beneficial in tumor growth reduction. The stimulation/inhibition of glycolysis in cancer is tightly regulated by ncRNAs. The regulation of glycolysis by ncRNAs can influence proliferation and therapy response of tumor. The miRNAs are capable of inactivating enzymes responsible for glycolysis and suppressing signaling networks resulting in glycolysis induction. By regulation of glycolysis, miRNAs can affect therapy response. The lncRNAs and circRNAs follow a same pathway and by targeting glycolysis, they affect progression and therapy response of tumor. Noteworthy, lncRNAs and circRNAs sponge miRNAs in glycolysis mechanism control in tumor cells. Furthermore, ncRNA-mediated regulation of glycolysis mechanism can influence metastasis to organs of body. The ncRNAs regulating glycolysis are reliable biomarkers in cancer patients and more importantly, exosomal ncRNAs due to their presence in body fluids, are minimally-invasive biomarkers.Copyright © 2023 Elsevier GmbH. All rights reserved.