目前在肝癌研究方面，猪模型的进展。
Current progress of pig models for liver cancer research.
发表日期：2023 Aug 01
作者：
Luyao Wang, Yuexian Piao, Fucheng Guo, Jiarui Wei, Yurong Chen, Xiangpeng Dai, Xiaoling Zhang
来源：
Disease Models & Mechanisms
摘要：
临床前试验在评估新的治疗策略对于包括肝癌在内的人类疾病的安全性和效果方面起着至关重要的作用。然而，大多数在临床前癌症模型中被证明有效的治疗策略在人类临床试验中失败，原因是缺乏适当的疾病动物模型。因此，开发一个精确的肝癌临床前动物模型非常重要且迫切。肝癌是一种诊断率高、5年生存率低的癌症。最近，猪因其与人类在身体大小、解剖特征、生理和病理生理方面的相似性，在生物医学研究中引起了越来越多的关注。猪肝癌模型可能为生物医学研究提供一个有前景的平台。在本综述中，我们全面总结和讨论了用于肝癌研究的猪模型的优点和缺点、原理、现状和进展。版权所有©2023作者。由Elsevier Masson SAS出版。保留所有权利。
Preclinical trials play critical roles in assessing the safety and efficiency of novel therapeutic strategies for human diseases including live cancer. However, most therapeutic strategies that were proved to be effective in preclinical cancer models failed in human clinical trials due to the lack of appropriate disease animal models. Therefore, it is of importance and urgent to develop a precise animal model for preclinical cancer research. Liver cancer is one of the most frequently diagnosed cancers with low 5-year survival rate. Recently, porcine attracted increasing attentions as animal model in biomedical research. Porcine liver cancer model may provide a promising platform for biomedical research due to their similarities to human being in body size, anatomical characteristics, physiology and pathophysiology. In this review, we comprehensively summarized and discussed the advantages and disadvantages, rationale, current status and progress of pig models for liver cancer research.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.