乳腺癌治疗中凝集素的治疗潜力：综述。
Therapeutic potential of lectins in the treatment of breast cancer: A review.
发表日期：2023 Aug 01
作者：
Suna Bektas, Engin Kaptan
来源：
Int J Biol Macromol
摘要：
乳腺癌是最常见的恶性肿瘤之一，也是导致女性癌症相关死亡的主要原因。乳腺癌有3个主要亚型，通过雌激素或孕激素受体的表达以及ERBB2基因扩增来区分。这3个亚型具有不同的风险特征和治疗策略。异常糖基化被认为在乳腺癌的肿瘤发生和转移性表型以及对治疗的耐药性中起重要作用。它们也可能是乳腺癌治疗的潜在吸引人的靶点。蛋白质，如凝集素，是一类存在于从病毒到人类等各种生物体中的特异性与癌细胞中异常糖基化糖残基相互作用并诱导细胞毒性效应的糖结合蛋白家族。近年来，有越来越多的研究证明它们对抗肿瘤和恶性特征的作用。本综述总结了来自植物、动物、真菌和细菌的凝集素的最新发现，这些凝集素有潜在的治疗乳腺癌的作用，并概述了它们的作用机制基础。版权所有© 2023，由Elsevier B.V.出版。
Breast cancer is one of the most common malignancies and the leading cause of cancer-related deaths in women. There are 3 major subtypes of breast cancer that are distinguished by expression of estrogen or progesterone receptors and ERBB2 gene amplification. The 3 subtypes have different risk profiles and treatment strategies. Abnormal glycosylation is thought to play an important role in the development of the tumorigenic and metastatic phenotype of breast cancer and resistance to therapy. They may also be a potentially attractive target for breast cancer treatment. Proteins such as lectins, a family of carbohydrate-binding proteins found in a variety of organisms from viruses to humans, can specifically interact with abnormally glycosylated carbohydrate residues in cancer cells and induce cytotoxic effects. In recent years, there has been a growing number of research addressing studies demonstrating their antitumorigenic and antimalignant effects. This review summarizes recent findings on lectins from plants, animals, fungi, and bacteria that are potentially therapeutic agents against breast cancer and outlines the basis of their mechanism of action.Copyright © 2023. Published by Elsevier B.V.