蛋白激酶Cα在病理生理条件和治疗干预中的潜在影响。
Potential implications of protein kinase Cα in pathophysiological conditions and therapeutic interventions.
发表日期：2023 Aug 01
作者：
Rishi Kant Singh, Sanjay Kumar, Sandeep Kumar, Alok Shukla, Naveen Kumar, Anand Kumar Patel, Lokesh Kumar Yadav, Kaushlendra, Meera Antiwal, Arbind Acharya
来源：
DIABETES & METABOLISM
摘要：
PKCα是一个功能多样的分子，在细胞存活和细胞死亡中发挥重要作用，以维持细胞内稳态。PKCα的正常功能改变是许多病理的复杂发病机制的原因，包括癌症、心血管疾病、肾脏并发症、神经退行性疾病、糖尿病等。多年来，已对该激酶在正常生理和病理条件下的功能和调控进行了多项研究。因此，大量具有相反结果的数据已经积累，形成了与PKCα功能相关的复杂的生理学含义框架，需要全面阐明。根据这些信息，本文对PKCα在基本细胞过程中的多重作用及其在各种病理条件下的分子机制进行了批判性分析。本综述进一步讨论了操纵患者PKCα信号幅度的当前方法，并提出PKCα作为逆转病理状态的治疗靶点。 版权所有 © 2023 Elsevier Inc. 发布
PKCα is a molecule with many functions that play an important role in cell survival and death to maintain cellular homeostasis. Alteration in the normal functioning of PKCα is responsible for the complicated etiology of many pathologies, including cancer, cardiovascular diseases, kidney complications, neurodegenerative diseases, diabetics, and many others. Several studies have been carried out over the years on this kinase's function, and regulation in normal physiology and pathological conditions. A lot of data with antithetical results have therefore accumulated over time to create a complex framework of physiological implications connected to the PKCα function that needs comprehensive elucidation. In light of this information, we critically analyze the multiple roles played by PKCα in basic cellular processes and their molecular mechanism during various pathological conditions. This review further discusses the current approaches to manipulating PKCα signaling amplitude in the patient's favour and proposed PKCα as a therapeutic target to reverse pathological states.Copyright © 2023. Published by Elsevier Inc.