尽管肥胖与许多疾病相关，但疾病的风险可能取决于新陈代谢健康状态。然而，对于新陈代谢健康状态是否影响中国一般人群患胃肠道癌症的风险尚不清楚。从开滦煤矿健康研究中包括符合条件的114,995名参与者。根据体质指数/腰围和代谢状态将研究参与者分为4组。通过回顾医疗记录，确认自2006年至2020年期间患胃肠道癌（食管癌，胃癌，肝癌，胆管癌，胰腺癌和结直肠癌）的事件。使用Cox比例风险回归模型计算危险比（HR）和95％置信区间（CI）评估新陈代谢健康状态与胃肠道癌症风险之间的关联。在平均13.76年的随访期间，我们记录了2,311例胃肠道癌症。多变量Cox回归分析显示，与MHNW组相比，MHO参与者通过体质指数类别表现出增加患胃肠道癌症的风险（HR 1.54，95％CI 1.11-2.13）。然而，在腰围类别中未发现这种关联。这些关联受年龄，性别和肿瘤部位的调节。MUNW或MUO表型个体也增加了患胃肠道癌症的风险。MHO表型与患胃肠道癌症的风险增加有关。此外，代谢不健康状态的个体患胃肠道癌症的风险也增加了。因此，临床医生应考虑到在代谢健康状态异常的人群中发生胃肠道癌症的风险，并就代谢适应性和体重控制向他们提供指导。 Note: While Simplified Chinese maintains the general structure and wording of the original passage, it is important to note that academic papers may have specific terminology and formatting requirements that should be considered when translating the entire document.

Although obesity is associated with numerous diseases, the risks of disease may depend on metabolically healthy status. Nevertheless, it is unclear to whether metabolically healthy status affects risk of gastrointestinal (GI) cancer in general Chinese population.A total of 114,995 participants who met the criteria were included from the Kailuan Study. The study participants were divided into 4 groups according to BMI/WC and metabolic status. Incident of GI cancer (esophageal cancer, gastric cancer, liver cancer, biliary cancer, pancreatic cancer and colorectal cancer) during 2006-2020 were confirmed by review of medical records. The Cox proportional hazard regression models were used to assess the association metabolically healthy status with the risk of GI cancer by calculating the hazard ratios (HR) and 95% confidence interval (CI).During a mean 13.76 years of follow-up, we documented 2,311 GI cancers. Multivariate Cox regression analysis showed that compared with the MHNW group, MHO participants demonstrated an increased risk of developing GI cancer(HR 1.54, 95%CI 1.11-2.13) by BMI categories. However, such associations were not found for WC category. These associations were moderated by age, gender and anatomical site of the tumor. Individuals with MUNW or MUO phenotype also have an increased risk of GI cancer.MHO phenotype was associated with increased risk of GI cancer. Moreover, individuals who complicated by metabolic unhealthy status have an increased risk of developing GI cancer. Hence, clinicians should consider the risk of incident GI cancer in people with abnormal metabolically healthy status and counsel them about metabolic fitness and weight control.