本研究的目的是探讨遵守两项癌症预防建议与癌症风险之间的关联。研究对象为2004年至2013年期间参与健康检验者-宝石研究的104,386名40-69岁个体。遵守得分是根据来自世界癌症研究基金会/美国癌症研究协会（WCRF/AICR）癌症预防建议的8个项目（包括体重、体力活动、饮食、饮酒和哺乳），以及韩国癌症预防指南的6个项目（吸烟状况、摄入蔬菜和水果、盐食物、饮酒量、体力活动和体重）构建的。使用Cox比例风险模型估计遵守得分与总体癌症和5种主要癌症风险之间的关联。男性遵守WCRF/AICR指南的高得分组（4.25-7 vs. 0-3.25）的多因素风险比（HR）为0.91（95% CI，0.82-1.00）。女性中最高得分组观察到降低的乳腺癌风险。男性韩国癌症预防指南得分最高类别（3.25-6.00）的HR为0.80（95% CI: 0.73-0.88），与得分最低类别（0-2.50）的男性相比，患总癌症的风险减少。男性最高遵守组显示出较低的胃癌、结直肠癌和肺癌发病风险。遵守癌症预防指南有助于降低韩国男性癌症发病风险，但该关联可能因癌症类型和性别而异。

The purpose of this study was to explore the association between adherence to 2 cancer prevention recommendations and cancer risk.In total, 104,386 individuals aged 40-69 years old who were recruited between 2004 and 2013 in the Health Examinees-Gem study were included. Adherence scores were constructed based on 8 items from the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) cancer prevention recommendations, including body weight, physical activity, diet, alcohol consumption and breastfeeding, and on 6 items from the Korean cancer prevention guidelines (smoking status, eating vegetables and fruits, salty foods, alcohol intake, physical activity, and body weight). A Cox proportional hazards model was used to estimate the associations between adherence scores and the risk of total and 5 major cancers.The multivariable hazard ratio (HR) for total cancer with the high adherence score versus the lowest score (4.25-7 vs. 0-3.25) for the WCRF/AICR guidelines was 0.91 (95% CI, 0.82-1.00) in men. A reduced breast cancer risk was observed among women with the highest score. Men within the highest category of the Korean cancer prevention guideline score (3.25-6.00) had an HR of 0.80 (95% CI: 0.73-0.88) for developing total cancer compared to men within the lowest score (0-2.50). The higher adherence group among men showed lower risks of developing stomach, colorectal, and lung cancers.Adhering to guidelines for cancer prevention can help to reduce the risk of developing cancer in Korean men. The association might differ by cancer type and sex.