自然多酚类化合物姜黄素（Curcumin），来源于姜黄（Curcuma longa L.），受到全球各地多个研究者的广泛关注，并已在临床层面上证实其在管理多种疾病中的巨大潜力。姜黄素的潜在作用机制涉及多种分子靶点的调节，包括炎症因子、转录因子、凋亡基因、生长因子、氧化应激生物标志物和蛋白激酶。临床试验表明，姜黄素作为辅助药物显著提高了多种已证实药物在关节炎、神经退行性疾病、口腔感染和胃肠疾病管理中的疗效。此外，临床研究表明，姜黄素通过调节信号分子（包括NF-kB、细胞因子、C-反应蛋白、前列腺素E2、Nrf2、HO-1、ALT、AST、激酶和血液指标）被认为是预防和/或治疗各种癌症的适当候选药物。本文重点介绍了关于姜黄素及其衍生物在多种疾病管理中进行的临床试验，并为未来的研究提供最新进展，以弥补当前存在的研究空白，推动姜黄素在具有不同病理状态的临床对象中的应用。© 2023 John Wiley & Sons Ltd.

Curcumin, a natural polyphenol, derived from Curcuma longa L. is extensively studied by various researchers across the globe and has established its immense potential in the management of several disorders at clinical level. The underlying mechanism of curcumin involves regulation of various molecular targets, namely, inflammatory cytokines, transcription factor, apoptotic genes, growth factors, oxidative stress biomarkers, and protein kinases. In clinical trials, curcumin as an adjuvant has significantly boost-up the efficacy of many proven drugs in the management of arthritis, neurodegenerative disorder, oral infection, and gastrointestinal disorders. Moreover, clinical studies have suggested curcumin as an appropriate candidate for the prevention and/or management of various cancers via regulation of signaling molecules including NF-kB, cytokines, C-reactive protein, prostaglandin E2, Nrf2, HO-1, ALT, AST, kinases, and blood profiles. This article highlights plethora of clinical trials that have been conducted on curcumin and its derivatives in the management of several ailments. Besides, it provides recent updates to the investigators for conducting future research to fulfill the current gaps to expedite the curcumin utility in clinical subjects bearing different pathological states.© 2023 John Wiley & Sons Ltd.