新冠病毒Omicron变异株的主要并发症是肺炎，然而，目前对Omicron相关肺炎的发病比例和预后影响因素尚未建立。我们进行了这项研究，旨在描述Omicron相关肺炎的发病比例，并评估不同因素对其预后的影响。我们收集了中国重庆医科大学附属第一医院(Omicron感染患者的数据，共计714例，并根据不同组别进行了分析。我们在经诊断为Omicron感染患者中确认了313例患有Omicron相关肺炎，占整个队列的43.8%。其中，年龄在15-59岁的有82例，60-69岁的有71例，70-79岁的有76例，>80岁的有84例。女性患者133例，男性患者180例。患有心血管疾病的患者中肺炎的发病比例最高(占心血管系统基础疾病子集的82.4%)，其次是患有肾病的患者(占肾病子集的92.3%)，而患有肺癌的患者的发病比例较低(占肺癌子集的35.7%)。与Omicron感染患者肺炎的预后相关的因素有多个。具有血栓形成或胸腔积液的患者住院时间较长。Paxlovid和免疫球蛋白可以改善重症肺炎患者的预后。在疾病严重程度方面，中性粒细胞和淋巴细胞数量、部分氧分压以及肌红蛋白、乳酸脱氢酶、门冬氨酸转氨酶和降钙素原水平等指标在患者之间存在显著差异。与Omicron感染患者相关心血管或肾脏疾病的患者发病比例较高，而与呼吸系统疾病无关的患者发病比例较低。Paxlovid和免疫球蛋白可用于重度感染患者以改善预后。© 作者(或其雇主) 2023。仅限在CC BY-NC下重复使用，不得进行商业再利用。由BMJ出版。

Pneumonia is the main complication of the Omicron variant of SARS-CoV-2; however, the incidence proportions and prognostic factors for Omicron-associated pneumonia have not been established. We conducted this study to characterise the incidence proportions and influence of various factors on prognosis of Omicron-associated pneumonia.We collected data from 714 patients infected with the Omicron variant in The First Affiliated Hospital of Chongqing Medical University (Chongqing, China) who were divided into different groups for analysis.We identified 313 patients with Omicron-associated pneumonia at the time of diagnosis of patients infected with the Omicron variant, representing 43.8% of the entire cohort. A total of 82 were 15-59 years old, 71 were 60-69 years old, 76 were 70-79 years old and 84 were >80 years old. 133 were female and 180 were male. Incidence proportions of pneumonia were highest among patients with cardiovascular (82.4% of the basic disease of the cardiovascular system subset) or kidney disease (92.3% of the kidney disease subset), whereas patients with lung cancer (35.7% of the lung cancer subset) had a lower incidence proportion. Several factors were associated with the prognosis of pneumonia in patients infected with the Omicron variant. Patients with a thrombosis or pleural effusion had a longer hospitalisation time. Paxlovid and immunoglobulins improved the prognosis of patients with severe pneumonia. The following measures were significantly different in patients as a function of disease severity: number of neutrophils and lymphocytes, partial oxygen pressure; and myoglobin, lactic dehydrogenase, aspartate transaminase and procalcitonin levels.Patients infected with the Omicron variant with coexisting cardiovascular or kidney disease, but not respiratory disease, had a higher incidence proportion of pneumonia. Paxlovid and immunoglobulins can be used in patients with severe infections to improve prognosis.© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.