黑人女性多地点队列研究中炎症相关暴露因素与卵巢癌生存率的关联
Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women.
发表日期:2023 Aug 03
作者:
Courtney E Johnson, Anthony J Alberg, Elisa V Bandera, Lauren C Peres, Maxwell Akonde, Lindsay J Collin, Michele L Cote, Theresa A Hastert, James R Hébert, Edward S Peters, Bonnie Qin, Paul Terry, Ann G Schwartz, Melissa Bondy, Michael P Epstein, Hannah B Mandle, Jeffrey R Marks, Andrew B Lawson, Joellen M Schildkraut
来源:
BRITISH JOURNAL OF CANCER
摘要:
我们观察到一组以侵袭性上皮性卵巢癌(EOC)为主的白种妇女中,炎症相关风险评分(IRRS)与整体生存率(OS)较差之间存在关联。在此,我们评估了黑种妇女中IRRS与EOC之间的关联,黑种妇女中的炎症暴露频率更高且生存状况较差。分析包括来自非洲裔美国人癌症流行病学研究(AACES)的592名被诊断为EOC的黑种妇女。采用Cox比例风险模型计算IRRS与OS的风险比(HR)和95%置信区间(CI),同时调整相关协变量。此外,还评估了其他炎症相关暴露,包括能量调整的饮食炎症指数(E-DII)。
观察到剂量-反应趋势,显示较高的IRRS与较差的OS相关(每个四分位HR:1.11,95% CI:1.01-1.22)。将E-DII添加到模型中,减弱了IRRS与OS的关联,而较高的E-DII,即更加炎症性的饮食,与较短的OS相关(每个四分位HR:1.12,95% CI:1.02-1.24)。在两个指标上得分较高与较短的OS相关(HR:1.54,95% CI:1.16-2.06)。
炎症相关暴露水平较高与黑种妇女的EOC OS减少相关。© 2023. 作者(们)在此授予施普林格自然有限公司独家许可。
An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival.The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DIITM), were evaluated.A dose-response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01-1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02-1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16-2.06).Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women.© 2023. The Author(s), under exclusive licence to Springer Nature Limited.