花色素是一种独特的天然多酚化合物，广泛存在于植物中，并因其出色的抗氧化、抗癌、抗衰老、抗微生物和抗炎等特性，在生物医学、化妆品和食品行业中得到广泛应用。然而，在极端环境（如碱性pH值、高温和金属离子）下，花色素的降解限制了其物理化学稳定性和生物利用率。通过封装和与生物材料结合，可以有效稳定花色素以进行保护。有望的是，具有良好稳定性、优异生物容量和广泛来源的天然或人工设计的蛋白质和肽类是稳定花色素的潜在候选物。本综述重点介绍了蛋白质和肽类在花色素功能化和传递方面的最新进展、策略和展望，包括配方技术、物理化学稳定性增强、细胞摄取、生物利用率和生物活性开发等方面。有趣的是，由于肽的结构简单多样，肽与花色素之间的相互作用机制可以被阐明。本研究揭示了蛋白质/肽-花色素纳米粒子构建的机制，并扩展了花色素在营养和生物医学中的潜在应用。 © 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.

Anthocyanin, a unique natural polyphenol, is abundant in plants and widely utilized in biomedicine, cosmetics, and the food industry due to its excellent antioxidant, anticancer, antiaging, antimicrobial, and anti-inflammatory properties. However, the degradation of anthocyanin in an extreme environment, such as alkali pH, high temperatures, and metal ions, limits its physiochemical stabilities and bioavailabilities. Encapsulation and combining anthocyanin with biomaterials could efficiently stabilize anthocyanin for protection. Promisingly, natural or artificially designed proteins and peptides with favorable stabilities, excellent biocapacity, and wide sources are potential candidates to stabilize anthocyanin. This review focuses on recent progress, strategies, and perspectives on protein and peptide for anthocyanin functionalization and delivery, i.e., formulation technologies, physicochemical stability enhancement, cellular uptake, bioavailabilities, and biological activities development. Interestingly, due to the simplicity and diversity of peptide structure, the interaction mechanisms between peptide and anthocyanin could be illustrated. This work sheds light on the mechanism of protein/peptide-anthocyanin nanoparticle construction and expands on potential applications of anthocyanin in nutrition and biomedicine.© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.