栓皮栎属植物提取物作为对癌症具有潜在预防或治疗效果的策略：一项系统综述研究。
Quercus spp. extract as a promising preventive or therapeutic strategy for cancer: A systematic review.
发表日期：2023 Sep
作者：
Paula A Oliveira, Beatriz Medeiros-Fonseca, Carmen Vasconcelos-Nóbrega, Antonieta Alvarado, Maria João Pires, Helena Vala, Ana I R N A Barros, Ana I Faustino-Rocha
来源：
Environmental Technology & Innovation
摘要：
橡子在人类的饮食中传统上被使用，并被用于特定疾病的治疗。因此，本研究进行了一项系统回顾研究，调查橡树属植物提取物在癌症预防和治疗中的效果。对于涉及橡树属植物提取物在体外和体内癌症模型中的抗癌作用的原始记录进行了系统的文献搜索。在体内研究中评估了体成分、食物消耗、肿瘤发展和/或毒性，而在体外研究中评估了细胞毒性。少量研究和样本量较小使得得出可靠结论具有挑战性。总体而言，结果表明橡树属植物提取物对减少癌症发展具有积极影响。因此，需要进行更多使用不同癌细胞系和动物模型的研究，以探究橡子提取物在多种癌症类型中的疗效。此外，应评估在饮食中添加橡子粉末对乳腺癌动物模型的效果。
Acorns have traditionally been used in the human diet and for the treatment of specific diseases. Therefore, the present study performed a systematic review of studies which investigated the effects of Quercus spp. extracts in cancer prevention and treatment. A systematic literature search was performed for original records which addressed the anticancer effects of Quercus spp. extract in in vitro and in vivo cancer models. Body composition, food consumption, tumor development and/or toxicity were evaluated in in vivo studies, while cytotoxicity was evaluated in in vitro studies. Few studies and low sample sizes presented a challenge in the drawing of solid conclusions. Overall, the results suggested a positive impact of Quercus spp. extract, by reducing cancer development. Therefore, more studies with different cancer cell lines and animal models to address the efficacy of the acorn extracts in several types of cancer are required. Furthermore, the effects of acorn flour, incorporated in the diet, in an animal model of mammary cancer should be evaluated.