为了研究对恶性十二指肠胆管狭窄患者使用长覆盖胆管支架在技术可行性、安全性和疗效方面的可行性。本回顾性研究纳入了2019年2月至2020年11月期间连续招募的57位患者（男性34例，女性23例；平均年龄64岁，年龄范围32-85岁），其主要诊断为恶性十二指肠胆管狭窄。所有患者均接受了长（18或23厘米）覆盖胆管支架治疗。胆管支架置放术在所有57位患者中均获得了技术成功。总不良事件发生率为17.5%（57名患者中的10名）。55名患者（96.5%）成功实现了内部引流。患者的中位生存期和支架通畅时间分别为99天（95％可信区间[CI]，58-140天）和73天（95％CI，60-86天）。55名患者中有14名（25.5％）由于淤泥（n = 11），肿瘤过度生长（n = 1），长胆管支架塌陷（由随后插入的附加十二指肠支架引起；n = 1）或迅速进展的十二指肠癌（n = 1）而导致胆管支架功能障碍。单变量Cox比例风险模型未发现任何独立的胆管支架通畅预测因子。技术可行的在十二指肠支架插入后经皮插入后续胆管支架。长覆盖胆管支架的经皮插入对恶性十二指肠胆管狭窄患者是安全且有效的。对于恶性十二指肠胆管狭窄患者，无论是否进行十二指肠支架放置，经皮插入长覆盖胆管支架均是安全且有效的。经皮插入长覆盖胆管支架对于恶性十二指肠胆管狭窄患者是一种安全且有效的操作。57名患者的胆管支架置入成功，55名患者（96.5％）成功实现了内部引流。在恶性十二指肠胆管狭窄患者中，放置长覆盖胆管支架后的中位患者生存期和支架通畅时间分别为99天和73天。©2023年。作者，独家授权给欧洲放射学会。

To investigate the technical feasibility, safety, and efficacy of a long-covered biliary stent in patients with malignant duodenobiliary stricture.This retrospective study enrolled 57 consecutive patients (34 men, 23 women; mean age, 64 years; range, 32-85 years) who presented with malignant duodenobiliary stricture between February 2019 and November 2020. All patients were treated with a long (18 or 23 cm)-covered biliary stent.The biliary stent deployment was technically successful in all 57 patients. The overall adverse event rate was 17.5% (10 of 57 patients). Successful internal drainage was achieved in 55 (96.5%) of 57 patients. The median patient survival and stent patency times were 99 days (95% confidence interval [CI], 58-140 days) and 73 days (95% CI, 60-86 days), respectively. Fourteen (25.5%) of the fifty-five patients presented with biliary stent dysfunction due to sludge (n = 11), tumor overgrowth (n = 1), collapse of the long biliary stent by a subsequently inserted additional duodenal stent (n = 1), or rapidly progressed duodenal cancer (n = 1). A univariate Cox proportional hazards model did not reveal any independent predictor of biliary stent patency.Percutaneous insertion of a subsequent biliary stent was technically feasible after duodenal stent insertion. Percutaneous insertion of a long-covered biliary stent was safe and effective in patients with malignant duodenobiliary stricture.In patients with malignant duodenobiliary stricture, percutaneous insertion of a long-covered biliary stent was safe and effective regardless of duodenal stent placement.• Percutaneous insertion of long-covered biliary stents in patients with malignant duodenobiliary stricture is a safe and effective procedure. • Biliary stent deployment was technically successful in all 57 patients and successful internal drainage was achieved in 55 (96.5%) of 57 patients. • The median patient survival and stent patency times were 99 days and 73 days, respectively, after placement of a long-covered biliary stent in patients with duodenobiliary stricture.© 2023. The Author(s), under exclusive licence to European Society of Radiology.