除了二甲双胍具有降糖作用外，越来越多的研究表明，二甲双胍还具有一些令人兴奋的特性，如抗氧化能力、抗癌、基因组稳定性、抗炎和抗纤维化等，这些特性具有强大的治疗潜力，可以治疗除糖尿病以外的其他疾病。我们的目标是描述和评估二甲双胍对生物、化学物质、天然物质、药物、农药和辐射引起的毒性的保护和解毒功效。我们从Scopus、Web of Science、PubMed和Google Scholar数据库中进行了全面的检索，时间范围从开始到2023年3月8日。考虑了所有体外、体内和临床研究。许多研究表明，二甲双胍除了影响糖尿病外，还影响其他疾病。它是一种放射保护和化学保护药物，也影响病毒和细菌性疾病。它可以用于对抗与炎症相关和凋亡相关的异常，并对毒素产生的影响进行降低。除了降低血糖外，二甲双胍还可以减弱毒素对体重、炎症、凋亡、坏死、半胱氨酸天冬氨酸蛋白酶-3活化、细胞存活率、活性氧自由基（ROS）、NF-κB、TNF-α、多种白细胞介素、脂质谱以及许多酶活性（如过氧化物酶和超氧化物歧化酶）的影响。它还可以减轻肾脏、肝脏和结肠等许多毒素引起的组织病理损害。然而，在将二甲双胍用作其他疾病的治疗药物之前，还需要进行临床试验和人体研究。版权 © 2023 The Authors. Elsevier Masson SAS 发布，保留所有权利。

In addition to the anti-diabetic effect of metformin, a growing number of studies have shown that metformin has some exciting properties, such as anti-oxidative capabilities, anticancer, genomic stability, anti-inflammation, and anti-fibrosis, which have potent, that can treat other disorders other than diabetes mellitus. We aimed to describe and review the protective and antidotal efficacy of metformin against biologicals, chemicals, natural, medications, pesticides, and radiation-induced toxicities. A comprehensive search has been performed from Scopus, Web of Science, PubMed, and Google Scholar databases from inception to March 8, 2023. All in vitro, in vivo, and clinical studies were considered. Many studies suggest that metformin affects diseases other than diabetes. It is a radioprotective and chemoprotective drug that also affects viral and bacterial diseases. It can be used against inflammation-related and apoptosis-related abnormalities and against toxins to lower their effects. Besides lowering blood sugar, metformin can attenuate the effects of toxins on body weight, inflammation, apoptosis, necrosis, caspase-3 activation, cell viability and survival rate, reactive oxygen species (ROS), NF-κB, TNF-α, many interleukins, lipid profile, and many enzymes activity such as catalase and superoxide dismutase. It also can reduce the histopathological damages induced by many toxins on the kidneys, liver, and colon. However, clinical trials and human studies are needed before using metformin as a therapeutic agent against other diseases.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.