淋巴结转移已被证明与许多癌症的预后呈正相关。然而，在临床治疗中，淋巴结清扫并不总是成功的，这表明肿瘤和哨兵淋巴结中的免疫细胞仍在肿瘤免疫抑制过程中起着关键作用。最近的研究表明，肿瘤可以通过多种策略耐受免疫细胞，包括肿瘤诱导的巨噬细胞再编程、T细胞失活、B细胞产生致病性抗体以及激活调节性T细胞来促进肿瘤在淋巴结中的定植、生长和转移。我们回顾了免疫细胞在淋巴结转移过程中对抗肿瘤或促进癌细胞转移的双向影响，以及恶性癌细胞改变免疫细胞的机制，为肿瘤细胞的生长和存活创造更有利的环境。此外，本文还将讨论在淋巴结转移中针对淋巴结中的免疫系统和潜在免疫靶点的研究和治疗策略。版权 © 2023. Elsevier Inc. 发布。

Lymph node metastasis has been shown to positively associated with the prognosis of many cancers. However, in clinical treatment, lymphadenectomy is not always successful, suggesting that immune cells in the tumor and sentinel lymph nodes still play a pivotal role in tumor immunosuppression. Recent studies had shown that tumors can tolerate immune cells through multiple strategies, including tumor-induced macrophage reprogramming, T cells inactivation, production of B cells pathogenic antibodies and activation of regulatory T cells to promote tumor colonization, growth, and metastasis in lymph nodes. We reviewed the bidirectional effect of immune cells on anti-tumor or promotion of cancer cell metastasis during lymph node metastasis, and the mechanisms by which malignant cancer cells modify immune cells to create a more favorable environment for the growth and survival of cancer cells. Research and treatment strategies focusing on the immune system in lymph nodes and potential immune targets in lymph node metastasis were also be discussed.Copyright © 2023. Published by Elsevier Inc.