肿瘤微环境（TME）的重编程是癌症的一个特点。代谢重编程是维持TME能量供应的重要方法。这种改变存在于癌细胞和TME细胞中，共同建立了一个免疫耐受的生态位，促进了肿瘤的进展。有限的资源导致代谢竞争，并阻碍了抗肿瘤免疫的生物功能。脂质代谢重编程和肿瘤进展密切相关。由于脂肪酸（FA）类型的复杂性和缺乏有效的检测方法，FA代谢重编程的机制和效应尚不清楚。在本文中，我们对肿瘤微环境中的FA代谢进行了综述，总结了FA代谢重编程如何影响抗肿瘤免疫反应，提出了FA如何影响癌症免疫治疗的机制，并讨论了以FA代谢为基础的抗癌药物的潜力。 版权所有 © 2023 Elsevier B.V. 出版。

Reprogramming of the tumor microenvironment (TME) is a hallmark of cancer. Metabolic reprogramming is a vital approach to sustaining the energy supply in the TME. This alteration exists in both cancer cells and TME cells, collectively establishing an immunotolerant niche to facilitate tumor progression. Limited resources lead to metabolic competition and hinder the biological functions of anti-tumoral immunity. Reprogramming of lipid metabolism and tumor progression is closely related to each other. Due to the complexity of fatty acid (FA) types and the lack of an effective approach for detection, the mechanisms and effects of FA metabolic reprogramming have been unclear. Herein, we review FA metabolism in the tumor milieu, summarize how FA metabolic reprogramming influences antitumor immune response, suggest the mechanisms by which FAs affect immunotherapy against cancer, and discuss the potential of FA metabolism-based drugs in cancer treatment.Copyright © 2023. Published by Elsevier B.V.