炎性脂肪因子和细胞因子在联系肥胖和女性乳腺癌（BC）风险中起着关键作用。我们调查了BMI变化与与BC风险相关的炎性生物标志物轨迹之间的纵向关联。我们对442名中国女性进行了为期3年的纵向研究，从2019年到2021年进行了重复测量。年度检测血浆循环与BC风险相关的炎性生物标志物，包括脂联素（ADP），抗糖尿酮（RETN），可溶性瘦素受体（sOB-R），胰岛素样生长因子结合蛋白-3（IGFBP-3）和C-反应蛋白（CRP）。线性混合效应模型（LMM）被用来研究时变的BMI与生物标志物轨迹的关联。我们还研究了基线BMI组、绝经状态和代谢综合征的修饰效应。在基线时，BMI与RETN、CRP、sOB-R的水平增加以及ADP的水平降低相关。BMI的增长速率与RETN的平均3年增加（β = 0.019，95% CI 0.004至0.034）、sOB-R的平均3年增加（β = 0.022，95% CI 0.009至0.035）以及ADP的降低（β = -0.006，95% CI -0.012至0.001）显著相关。这些关联在不同的基线BMI组中持续存在。BMI的增长速率与正常体重女性（β = 0.045，95% CI 0.001至0.088）和超重女性（β = 0.060，95% CI 0.014至0.107）的CRP水平的平均3年增加显著相关。随着BMI随时间的增加，在基线时患有代谢综合征的女性中，ADP的降低更为显著（β = -0.016，95% CI -0.029至-0.004）。BMI增加速度更高与与BC风险相关的炎性生物标志物的恶化轨迹相关。减肥的建议可能有益于妇女的BC预防，特别是对于那些患有代谢综合征的人而言。© 2023年作者（受Springer科学商业媒体有限公司和Springer Nature的独家许可）

Inflammatory adipokines and cytokines play a pivotal role in linking obesity and breast cancer (BC) risk in women. We investigated the longitudinal associations between BMI change and trajectories of inflammatory biomarkers related to BC risk.A longitudinal study was conducted among 442 Chinese women with 3-year repeated measures from 2019 to 2021. Plasma circulating inflammatory biomarkers related to BC risk, including adiponectin (ADP), resistin (RETN), soluble leptin receptor (sOB-R), insulin-like growth factor-binding protein-3 (IGFBP-3), and C-reactive protein (CRP), were examined annually. Linear mixed-effect models (LMM) were applied to investigate associations of time-varying BMI with trajectories of biomarkers. We additionally examined the modification effect of baseline BMI groups, menopausal status, and metabolic syndrome.BMI was associated with increased levels of RETN, CRP, sOB-R, and decreased levels of ADP at baseline. An increasing BMI rate was significantly associated with an average 3-year increase in RETN (β = 0.019, 95% CI 0.004 to 0.034) and sOB-R (β = 0.022, 95% CI 0.009 to 0.035), as well as a decrease in ADP (β =  - 0.006, 95% CI  - 0.012 to 0.001). These associations persisted across different baseline BMI groups. An increasing BMI rate was significantly associated with an average 3-year increase in CRP levels among normal weight (β = 0.045, 95% CI 0.001 to 0.088) and overweight (β = 0.060, 95% CI 0.014 to 0.107) women. As BMI increased over time, a more remarkable decrease in ADP was observed among women with metabolic syndrome (β =  - 0.016, 95% CI - 0.029 to - 0.004) than those without metabolic syndrome at baseline.A higher increase rate of BMI was associated with poorer trajectories of inflammatory biomarkers related to BC risk. Recommendations for BMI reduction may benefit BC prevention in women, particularly for those with metabolic syndrome.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.