目前有关青少年和年轻成人（AYA）癌症幸存者的存活指南是基于在美国和欧洲进行的研究结果。然而，以往的研究表明，癌症幸存者的健康相关生活质量可能会因种族不同而有所差异，然而对于不同种族/民族的AYA幸存者之间的长期健康差异尚未得到充分探究。因此，我们的目标是比较不同种族和民族群体中AYA幸存者及其匹配对照组在心理社会和身体健康方面的差异。我们利用美国国家健康和营养调查（NHANES）和韩国NHANES于2007至2018年间进行了一项横断面研究。我们包括了年龄在15至39岁之间被诊断为任何类型癌症的AYA幸存者，并且在调查年龄超过18岁的成年人。然后，我们按种族/民族将研究人群分层为非西班牙裔白人（NHW，n = 310），非洲裔美国人（AA，n = 42），来自NHANES的西班牙裔（n = 81），以及来自韩国NHANES的亚洲人（n = 389）。我们还选取了从未被诊断为癌症的参与者中与年龄、性别、种族和调查年份相匹配的一般人口（N = 4110）的5倍。变量是通过问卷调查数据、体格检查和实验室测试来定义的。 与NHW相比，西班牙裔（aOR 1.15，95% CI 1.00-1.32）的一般健康状况较差，教育水平较低（aOR 1.23，95% CI 1.07-1.40），家庭收入较低（aOR 1.16，95% CI 1.01-1.33）。AA幸存者更有可能未婚（aOR 1.35，95% 1.15-1.60）并患有高血压（aOR 1.18，95% CI 1.03-1.36）。亚洲人更多是以前/现在的饮酒者（aOR 1.21，95% CI 1.05-1.40）。NHW更有可能经历心理限制。与匹配的一般人口相比，NHW和亚洲幸存者的总体健康和心理健康较差。本研究为未来研究提供了关于AYA幸存者长期健康问题的证据，这些问题可能因种族不同而有所不同。 © 2023. BioMed Central Ltd., part of Springer Nature.

The current guidelines for survivorship in adolescents and young adults (AYA) cancer are based on studies conducted in the United States and European AYA survivors. However, previous studies have shown that the health-related quality of life in cancer survivors can vary depending on race, yet the long-term health differences among AYA survivors by race/ethnicity have not been fully explored. Therefore, our aim is to compare the psychosocial and physical health of AYA survivors and their matched controls across different racial and ethnic groups.We conducted a cross-sectional study using US National Health and Nutrition Examination Survey (NHANES) and the Korea NHANES from 2007 to 2018. We included AYA cancer survivors who were diagnosed with any type of cancer aged between 15 and 39 years, and who were adult with aged over 18 years old at survey year. We then stratified the study population by race/ethnicity with Non-Hispanic White (NHW, n = 310), African American (AA, n = 42), Hispanic (n = 81) from NHANES, and Asian (n = 389) from the Korea NHANES. We also selected 5 times age-, sex-, race-, and survey year-matched general population among participants who had never been diagnosed with cancer (N = 4110). Variables were defined using questionnaire data, physical exams, and laboratory tests.Compared to NHW, Hispanics (aOR 1.15, 95% CI 1.00-1.32) had poor or fair general health, lower education (aOR 1.23, 95% CI 1.07-1.40), and lower household income (aOR 1.16, 95% CI 1.01-1.33). AA survivors were more likely to be non-coupled (aOR 1.35, 95% 1.15-1.60) and have hypertension (aOR 1.18, 95% CI 1.03-1.36). Asians were more former/current drinkers (aOR 1.21, 95% CI 1.05-1.40). NHW are more likely to experience psychological limitation. Compared to matched general, NHW and Asian survivors had poor general health and psychological health.This study provides evidence for future studies concerning long-term health after AYA cancer survivorship that may vary according to race.© 2023. BioMed Central Ltd., part of Springer Nature.