B-cell lymphoma 2-associated athanogene-3（Bag3）在所有动物种类中均有表达，其中在心脏、骨骼肌、中枢神经系统和许多癌症中，Bag3水平最为突出。Bag3生物学的临床前研究主要集中在发生心脏功能受损的动物身上；然而，本研究旨在识别在心脏出现临床病征之前，这些临床征兆之前发生的心脏病变途径。这些研究表明，携带BAG3基因一个等位基因敲除变异的心脏在多个细胞通路中发生显著变化，包括细胞凋亡、自噬、线粒体稳态和炎性小体。© 2023作者。

B-cell lymphoma 2-associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised cardiac function; however, the present studies were performed to identify the pathways perturbed in the heart even before the occurrence of clinical signs of dilatation and failure of the heart. These studies show that hearts carrying variants that knockout one allele of BAG3 have significant alterations in multiple cellular pathways including apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome.© 2023 The Authors.