慢性阻塞性肺疾病（COPD）患者表现出肌肉功能障碍和肌肉氧化能力受损，导致运动能力降低和健康状况差。本研究的目的是比较中度COPD患者的身体表现、全身炎症和氧化应激情况，并将身体表现与炎症和氧化应激等因素相关联。本研究共有20例参与者，其中CONTROL组10例，中度COPD组10例。测量了系统性炎症和氧化应激指标、最大耐力（VO2peak）和膝伸肌最大等长收缩力（MVIC）。CONTROL组的VO2peak比COPD组高31.3%（P = 0.006）。CONTROL组的膝伸肌MVIC力量比COPD组高43.9%（P = 0.002）。COPD组的肿瘤坏死因子-α（TNF-α）水平比CONTROL组高79.6%（P < 0.001）。谷胱甘肽过氧化物酶（GPx）活性比CONTROL组低27.5%（P = 0.05）。TNF-α浓度与膝伸肌MVIC力量（R = -0.48，P = 0.045）和VO2peak（R = -0.58，P = 0.01）呈负相关。与此同时，丙二醛（MDA）和GPx活性与膝伸肌力量或VO2peak无相关性（P = 0.74和P = 0.14）。COPD患者的肌肉力量和有氧能力较健康对照个体较差。此外，COPD患者全身系统性炎症水平较高，抗氧化能力较低。炎症水平与身体表现变量之间存在中度相关性。© 2023. 作者，由Springer Nature Switzerland AG独家许可。

Chronic obstructive pulmonary disease (COPD) patients manifest muscle dysfunction and impaired muscle oxidative capacity, which result in reduced exercise capacity and poor health status. The aim of this study was to compare the physical performance, systemic inflammation, and oxidative stress of patients with moderate COPD, and to associate physical performance with inflammatory and oxidative stress plasma markers. Twenty CONTROL (n = 10) and moderate COPD (n = 10) patients participated in this study. Systematic inflammation and oxidative stress plasma markers, maximal aerobic capacity (VO2peak), and maximal isometric strength (MVIC) of the knee extensor (KE) muscles were measured. VO2peak was 31.3% greater in CONTROL compared to COPD (P = 0.006). The MVIC strength of the KE was 43.9% greater in CONTROL compared to COPD (P = 0.002). Tumor necrosis factor-alpha (TNF-α) was 79.6% greater in COPD compared to CONTROL (P < 0.001). Glutathione peroxidase activity (GPx) activity was 27.5% lesser in COPD compared to CONTROL (P = 0.05). TNF-α concentration was correlated with KE MVC strength (R = -0.48; P = 0.045) and VO2peak (R = -0.58; P = 0.01). Meanwhile, malondialdehyde (MDA) and GPx activity were not associated with KE strength or VO2peak (P = 0.74 and P = 0.14, respectively). COPD patients showed lesser muscle strength and aerobic capacity than healthy control individuals. Furthermore, patients with COPD showed greater systemic inflammation and lesser antioxidant capacity than healthy counterparts. A moderate association was evident between levels of systemic inflammation and physical performance variables.© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.