系统免疫状态影响肿瘤细胞的消除。然而，过敏性疾病中的慢性炎症如何影响肿瘤微环境和肿瘤发生机制仍不清楚。为了研究过敏性炎症状态下的肿瘤进展，我们建立了小鼠过敏性炎症模型。我们使用家尘螨提取物诱导超敏系统免疫反应，同时皮下接种两种类型的癌细胞（CT26和4T1肿瘤）。我们使用多色流式细胞术对体外肿瘤组织进行免疫特征分析，并进行外周细胞因子的动态分析，探索过敏性炎症发展与肿瘤发生之间的显著关系。我们发现，处于过敏性炎症状态的小鼠更易于发展肿瘤。有趣的是，在过敏状态下，T细胞炎症抑制性生长，而非T细胞炎症促进增长。进一步的研究揭示，具有增强肿瘤杀伤或免疫调节能力的自然杀伤（NK）细胞在“热”肿瘤中更活跃。抑制NK细胞活性可以部分减轻过敏性炎症对肿瘤生长的影响。总之，我们的结果表明，在过敏性炎症小鼠模型中，NK细胞在抑制肿瘤生长中起到重要作用。这一现象似乎与肿瘤的固有特性及其与免疫系统的相互作用密切相关。先天免疫系统可以与适应性免疫系统协同作用，抑制肿瘤生长，为肿瘤免疫疗法开辟了新途径。 版权所有 © 2023 Elsevier B.V. 保留所有权利。

Systemic immune status influences the elimination of tumor cells. However, it remains unclear how chronic inflammation in allergic diseases affects the tumor microenvironment and tumorigenesis. To investigate tumor progression in a state of heightened allergic inflammation, we established a mouse model of allergic inflammation. We used house dust mite extract to induce a hyper-reactive systemic immune response. Additionally, we subcutaneously inoculated two types of cancer cells (CT26 and 4T1 tumors). We conducted immune profiling of the ex-vivo tumor mass using multicolor flow cytometry staining and performed dynamic analysis of peripheral cytokines to explore the significant relationship between the development of allergic inflammation and tumorigenesis. We found that mice in a state of allergic inflammation were more susceptible to developing tumors. Interestingly, the growth of T cell-inflamed was inhibited in the allergic state, while growth of non-T cell-inflamed was promoted. Further research revealed that natural killer (NK) cells with enhanced tumor-killing or immune-regulating abilities were more active in " hot " tumors. Inhibiting NK cell activity can partially alleviate the impact of allergic inflammation on tumor growth. In summary, our results suggest that NK cells play significant role in suppressing tumor growth in an allergic inflammation mouse model. This phenomenon seems to be closely linked to both the inherent characteristics of the tumor and its interaction with the immune system. The innate immune system can be mobilized to synergize with the adaptive immune system to inhibit tumor growth, which opens a new way for a tumor immunotherapy.Copyright © 2023 Elsevier B.V. All rights reserved.