针对颅骨切除术后体重指数（BMI）与术后死亡率的关联性，特别是在亚洲人群中，缺乏证据。我们的研究旨在探讨在接受颅骨切除术治疗脑肿瘤切除的中国患者中，BMI与术后30天死亡率的关联。本研究为一项大型回顾性队列研究，补充资料9，来源网址：http://links.lww.com/JNA/A634，收集了7519例接受颅骨切除术治疗脑肿瘤切除的患者的数据。根据世界卫生组织亚洲人群肥胖标准，将纳入研究的患者分类为体重过轻（<18.5 kg/m²）、正常体重（18.5至22.9 kg/m²）、超重（23至24.9 kg/m²）、肥胖I级（25至29.9 kg/m²）和肥胖II级（≥30 kg/m²）。我们使用多变量 logistic 回归模型探索不同 BMI 分组与术后30天死亡率之间的关联。此外，我们还根据年龄和性别进行分层分析。超重（调整后的奥斯比比值为0.63，95%置信区间为0.40-0.99）和肥胖I级（调整后的奥斯比比值为0.44，95%置信区间为0.28-0.72）与正常体重相比，与术后30天死亡率降低相关。这种关联在年轻患者（年龄低于65岁）中更为显著，而并非在老年患者中，年龄与超重与正常体重在死亡率上存在交互作用（交互作用的P值为0.04）。 我们发现，在接受颅骨切除术治疗脑肿瘤的中国患者中，BMI与术后30天死亡率呈J型关联，27 kg/m²时死亡率最低。此外，在年轻患者中，超重和肥胖I级均与30天死亡风险降低相关。 版权所有 © 2023 Wolters Kluwer Health，Inc. 保留所有权利。

There is little evidence regarding the association of body mass index (BMI) with postoperative mortality after craniotomy, especially in the Asian population. Our study aimed to explore the association between BMI and postoperative 30-day mortality in Chinese patients undergoing craniotomy for brain tumor resection.This large retrospective cohort study, Supplemental Digital Content 9, http://links.lww.com/JNA/A634 collected data from 7519 patients who underwent craniotomy for brain tumor resection. On the basis of the World Health Organization obesity criteria for Asians, included patients were categorized as underweight (<18.5 kg/m2), normal weight (18.5 to 22.9 kg/m2), overweight (23to 24.9 kg/m2), obese I (25 to 29.9 kg/m2), and obese II (≥30 kg/m2). We used a multivariable logistic regression model to explore the association between different BMI categories and 30-day postoperative mortality. In addition, we also conducted stratified analyses based on age and sex.Overweight (adjusted odds ratio 0.63, 95% CI 0.40-0.99) and obese I (adjusted odds ratio 0.44, 95% CI 0.28-0.72) were associated with decreased 30-day postoperative mortality compared with normal-weight counterparts. Such associations were prominent among younger (age younger than 65 y) patients but not older patients, and there was an interaction between age and overweight versus normal weight on mortality (P for interaction=0.04).We found that among Chinese patients undergoing craniotomy for brain tumors, there was a J-shaped association between BMI and postoperative 30-day mortality, with lowest mortality at 27 kg/m². Moreover, in young patients, overweight and obese I were both associated with decreased risk of 30-day mortality.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.