胰岛素生长因子2 mRNA结合蛋白（IGF2BPs）作为转录后调控的执行者在维持或获得肿瘤特征方面发挥着重要的生物功能，这是由于它们独特的蛋白结构。新兴证据表明IGF2BPs属于RNA N6-甲基腺苷（m6A）修饰三类阅读蛋白，参与多个重要生物进程中的RNA稳定性、存储、定位、代谢和翻译的调控，特别是在肿瘤发生和进展过程中发挥作用。本文讨论了IGF2BPs作为m6A阅读蛋白在肿瘤发病机制和多药耐药性中的调控机制和病理功能。此外，我们强调IGF2BPs在临床肿瘤治疗中作为药物靶点的潜力。因此，通过靶向表观遗传异质性，可以发现精确而新颖的肿瘤治疗方法。©作者。

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) serve essential biological functions as post-transcriptional performers, participating in the acquisition or maintenance of tumor hallmarks due to their distinct protein structures. Emerging evidence indicates that IGF2BPs belong to the class III type of RNA N6-methyladenosine (m6A) modification readers, controlling RNA stability, storage, localization, metabolism, and translation in multiple vital bioprocesses, particularly tumorigenesis and tumor progression. Here, we discuss the underlying regulatory mechanisms and pathological functions of IGF2BPs which act as m6A readers in the context of tumor pathogenesis and multidrug resistance. Furthermore, we highlight the potential of IGF2BPs as drug targets in clinical tumor treatment. Hence, precise and novel tumor therapeutic approaches could be uncovered by targeting epigenetic heterogeneity.© The author(s).