肿瘤坏死因子-alpha（TNF-α）在人体广泛存在，对各种生理和病理过程起着重要作用。然而，由于其机制的复杂性，TNF-α引起的疾病仍了解不足，疗效也有限。N6-甲基腺苷（m6A）甲基化是mRNA的一种普遍的表观遗传修饰类型，主要发生在转录后水平，并涉及细胞核内和细胞核外的mRNA代谢。证据表明，m6A甲基化参与了TNF-α引起的疾病和与TNF-α相关的信号通路。本综述总结了TNF-α和m6A甲基化调节因子在各种疾病中的参与情况，研究了m6A甲基化对TNF-α引起的疾病的影响，并提出了治疗TNF-α引起的疾病的潜在治疗靶点。版权所有 © 2023 Wang, Liu and Wang.

Tumor Necrosis Factor-alpha (TNF-α) is ubiquitous in the human body and plays a significant role in various physiological and pathological processes. However, TNF-α-induced diseases remain poorly understood with limited efficacy due to the intricate nature of their mechanisms. N6-methyladenosine (m6A) methylation, a prevalent type of epigenetic modification of mRNA, primarily occurs at the post-transcriptional level and is involved in intranuclear and extranuclear mRNA metabolism. Evidence suggests that m6A methylation participates in TNF-α-induced diseases and signaling pathways associated with TNF-α. This review summarizes the involvement of TNF-α and m6A methylation regulators in various diseases, investigates the impact of m6A methylation on TNF-α-induced diseases, and puts forth potential therapeutic targets for treating TNF-α-induced diseases.Copyright © 2023 Wang, Liu and Wang.