SIRT1 是哺乳动物中保守性最高的依赖于NAD+的蛋白去乙酰化酶。通过去乙酰化转录因子和辅因子，这种蛋白质修饰酶在代谢和表观遗传调控干细胞过程中起着重要的作用，对其多能性的维持和调节分化起到关键作用。C-Myc 是Myc原癌基因家族的一个关键成员，是控制干细胞获取和维持的基因的转录调控重要因子。先前的癌症研究揭示了SIRT1 和 c-Myc 之间一个引人注目的正向反馈环路，对肿瘤发生起关键作用。最新文献揭示了这个轴在干细胞的维持和分化调控中的重要功能，包括多能干细胞和癌症干细胞。本综述论文重点介绍了SIRT1-c-Myc 轴在干细胞中的最新进展。版权所有 © 2023 Fan and Li.

SIRT1 is the most conserved mammalian NAD+-dependent protein deacetylase. Through deacetylation of transcriptional factors and co-factors, this protein modification enzyme is critically involved in metabolic and epigenetic regulation of stem cells, which is functionally important in maintaining their pluripotency and regulating their differentiation. C-Myc, a key member of Myc proton-oncogene family, is a pivotal factor for transcriptional regulation of genes that control acquisition and maintenance of stemness. Previous cancer research has revealed an intriguing positive feedback loop between SIRT1 and c-Myc that is crucial in tumorigenesis. Recent literature has uncovered important functions of this axis in regulation of maintenance and differentiation of stem cells, including pluripotent stem cells and cancer stem cells. This review highlights recent advances of the SIRT1-c-Myc axis in stem cells.Copyright © 2023 Fan and Li.