研究动态
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放射性核素定位治疗、放射增敏剂和成像剂中的乳化技术。

Emulsion Technology in Nuclear Medicine: Targeted Radionuclide Therapies, Radiosensitizers, and Imaging Agents.

发表日期:2023
作者: Thunnalin Winuprasith, Pankaj Koirala, David J McClements, Piyachai Khomein
来源: International Journal of Nanomedicine

摘要:

放射性药物是核医学中诊断和治疗多种疾病,尤其是癌症的重要组成部分。目前,大多数放射性药物基于具有靶向能力的小分子。然而,一些关注点在于它们的稳定性或非特异性相互作用,导致了靶标定位的离靶问题,这是需要解决的主要挑战之一。乳化技术在制备放射性药物的载体系统方面具有巨大的潜力。它可以利用广泛被公认为安全(GRAS)的材料来创建具有不同成分、结构、尺寸和表面特性的微粒,从而可以调整其在特定应用场景下的功能性。特别是,可以进行表面修饰以引入靶向和隐秘性能,并控制微粒尺寸以操纵扩散和穿透性能。此外,乳化制备方法通常简单、经济、可靠且可扩展,非常适合医学应用。在本综述中,我们重点介绍乳化技术在核医学中用于开发靶向放射性核素治疗、用作放射增敏剂和在γ成像技术中用作放射示踪剂传递的潜力。© 2023 Winuprasith et al.
Radiopharmaceuticals serve as a major part of nuclear medicine contributing to both diagnosis and treatment of several diseases, especially cancers. Currently, most radiopharmaceuticals are based on small molecules with targeting ability. However, some concerns over their stability or non-specific interactions leading to off-target localization are among the major challenges that need to be overcome. Emulsion technology has great potential for the fabrication of carrier systems for radiopharmaceuticals. It can be used to create particles with different compositions, structures, sizes, and surface characteristics from a wide range of generally recognized as safe (GRAS) materials, which allows their functionality to be tuned for specific applications. In particular, it is possible to carry out surface modifications to introduce targeting and stealth properties, as well as to control the particle dimensions to manipulate diffusion and penetration properties. Moreover, emulsion preparation methods are usually simple, economic, robust, and scalable, which makes them suitable for medical applications. In this review, we highlight the potential of emulsion technology in nuclear medicine for developing targeted radionuclide therapies, for use as radiosensitizers, and for application in radiotracer delivery in gamma imaging techniques.© 2023 Winuprasith et al.