技师锝-99m（99mTc）二脱酸磷酸盐是用于骨扫描的最常见的放射性药物。尽管对骨组织的摄取已广泛研究，但在骨扫描期间可能会出现软组织恶性肿瘤的非典型摄取。增加的血管化和内皮通透性是示踪剂生物分布中的重要因素，尽管还发现了其他原因，如创伤、坏死、转移瘤中的钙化物质、组织的pH以及离子浓度类型。本文旨在总结肿瘤组织中非典型软组织摄取的最新研究成果。该研究在PubMed上进行。文献分析表明，钙代谢和离子饱和度在骨示踪剂生物分布中起着至关重要的作用。这一现象在包括癌变和癌症环境因素的复杂情境中排名靠前。我们还报告了我们机构中观察到的两例肿瘤组织中的非典型摄取情况。

Technetium-99m (99mTc)-diphosphonates represent the most common radiopharmaceutical used for bone scintigraphy. Even if the uptake in bone tissue has been widely explored, atypical uptake could be seen in soft tissue malignancies during bone scintigraphy. Increased vascularization and endothelium permeability represent front-row players in the biodistribution of the tracer, albeit other causes have been identified such as trauma, necrosis, the presence of calcification in metastasis, the pH of the tissue and consequently the type of ion concentration.The aim of this paper is to summarize the state of art of atypical soft tissue uptake seen in cancer tissues. The research was conducted on PubMed. The analysis of the literature suggests that calcium metabolism and ionic saturation have a pivotal role in the biodistribution of bone tracers. This phenomenon ranks in a complex scenario that includes carcinogenesis and cancer environment aspects. We also report two cases in our Institution in which atypical uptake in cancer tissues was observed.