非酒精性脂肪性肝炎（NASH）是一种慢性且不可治愈的肝病，主要由不适当的饮食和遗传因素引发，给肝脏代谢压力带来负担，可能导致肝纤维化甚至癌症。然而，现有药物存在不良副作用。从天然资源中提取的非毒性活性生物分子，尤其是海洋藻类多糖（MAPs），对治疗NASH具有显著潜力。在本综述中，我们从多个角度总结了MAPs对NASH的保护作用，包括减少氧化应激、调节脂质代谢、增强免疫功能、预防纤维化和提供细胞保护。此外，全面描述了MAPs治疗NASH的机制。此外，我们还强调了MAPs的特殊结构对其生物活性差异的影响。通过这一综合综述，我们旨在进一步阐明MAPs在NASH中的分子机制，并为对MAPs的功能食品和临床应用进行深入研究提供启示。版权所有 © 2023。Elsevier B.V.出版。

Non-alcoholic steatohepatitis (NASH) is one of the most chronic and incurable liver diseases triggered mainly by an inappropriate diet and hereditary factors which burden liver metabolic stress, and may result in liver fibrosis or even cancer. While the available drugs show adverse side effects. The non-toxic bioactive molecules derived from natural resources, particularly marine algal polysaccharides (MAPs), present significant potential for treating NASH. In this review, we summarized the protective effects of MAPs on NASH from multiple perspectives, including reducing oxidative stress, regulating lipid metabolism, enhancing immune function, preventing fibrosis, and providing cell protection. Furthermore, the mechanisms of MAPs in treating NASH were comprehensively described. Additionally, we highlight the influences of the special structures of MAPs on their bioactive differences. Through this comprehensive review, we aim to further elucidate the molecular mechanisms of MAPs in NASH and inspire insights for deeper research on the functional food and clinical applications of MAPs.Copyright © 2023. Published by Elsevier B.V.