激光散斑对比成像或激光散斑成像（LSI）是一种非侵入性成像技术，可以检测动态灌注或血管流量的区域。因此，LSI在各种病理学中显示出越来越多的诊断价值，并已在许多医学专业中用于术中、术后和长期监测。最近，LSI在临床皮肤科领域引起了关注，因为与正常组织相比，它可以有效评估与增加灌注和高血管性相关的病理学。迄今为止，LSI已经被发现在监测皮肤移植再灌注、确定烧伤的严重程度、评估神经外科再灌注、评估激光治疗后毛细血管畸形持续灌注以及区别恶性和良性皮肤病变方面具有高准确性。LSI具有在更侵入性的诊断方法（如组织活检）之前非侵入性评估病变的优势，同时价格低廉且迄今为止不存在不良事件。然而，其临床使用可能面临的潜在障碍包括组织运动伪像、主要定性数据和与当前常规诊断方法相比缺乏优势数据对临床实践的影响不明确。在本综述中，我们讨论了LSI在皮肤科中的临床应用，用于诊断和监测血管、肿瘤和炎症性皮肤病变。 © 2023 The Authors.

Laser speckle contrast imaging or laser speckle imaging (LSI) is a noninvasive imaging technology that can detect areas of dynamic perfusion or vascular flow. Thus, LSI has shown increasing diagnostic utility in various pathologies and has been employed for intraoperative, postoperative, and long-term monitoring in many medical specialties. Recently, LSI has gained traction in clinical dermatology because it can be effective in the assessment of pathologies that are associated with increased perfusion and hypervascularity compared with that of normal tissue. To date, LSI has been found to be highly accurate in monitoring skin graft reperfusion, determining the severity of burns, evaluating neurosurgical revascularization, assessing persistent perfusion in capillary malformations after laser therapy, and differentiating malignant and benign skin lesions. LSI affords the advantage of noninvasively assessing lesions before more invasive methods of diagnosis, such as tissue biopsy, while remaining inexpensive and exhibiting no adverse events to date. However, potential obstacles to its clinical use include tissue movement artifact, primarily qualitative data, and unclear impact on clinical practice given the lack of superiority data compared with the current standard-of-care diagnostic methods. In this review, we discuss the clinical applications of LSI in dermatology for use in the diagnosis and monitoring of vascular, neoplastic, and inflammatory skin conditions.© 2023 The Authors.