铜是一种在许多生理过程中发挥关键作用的必需微量营养素。然而，癌细胞中过量的铜积累与肿瘤生长和转移有关。本综述探讨了以铜代谢为靶点的癌症治疗作为一种有前景的策略。癌细胞中过量的铜积累与肿瘤生长和转移有关。通过干扰癌细胞中的铜稳态并通过铜依赖的机制（分别为铜生长异常和铜死亡）诱导细胞死亡，可以开发出具有更高疗效和较低副作用的疗法。该文讨论了铜在血管生成、免疫应答和氧化还原平衡等生物过程中的作用。该文考察了针对癌症治疗中铜代谢的各种方法，包括使用铜依赖性酶、铜基化合物和与铜死亡相关的基因或蛋白质。本文还探讨了铜螯合治疗和纳米技术用于靶向传递铜靶向药物等策略。通过了解铜死亡的复杂网络及其与肿瘤微环境和免疫系统的相互作用，可以找到新的治疗靶点，以提高癌症治疗效果。总体而言，本综述凸显了以铜代谢为靶点的癌症治疗作为一种有前景和有效的方法，并提供了该领域目前研究的有价值见解。版权所有 © 2023 Kong and Sun.

Copper is an essential micronutrient that plays a critical role in many physiological processes. However, excessive copper accumulation in cancer cells has been linked to tumor growth and metastasis. This review article explores the potential of targeting copper metabolism as a promising strategy for cancer treatment. Excessive copper accumulation in cancer cells has been associated with tumor growth and metastasis. By disrupting copper homeostasis in cancer cells and inducing cell death through copper-dependent mechanisms (cuproplasia and cuprotosis, respectively), therapies can be developed with improved efficacy and reduced side effects. The article discusses the role of copper in biological processes, such as angiogenesis, immune response, and redox homeostasis. Various approaches for targeting copper metabolism in cancer treatment are examined, including the use of copper-dependent enzymes, copper-based compounds, and cuprotosis-related genes or proteins. The review also explores strategies like copper chelation therapy and nanotechnology for targeted delivery of copper-targeting agents. By understanding the intricate network of cuprotosis and its interactions with the tumor microenvironment and immune system, new targets for therapy can be identified, leading to improved cancer treatment outcomes. Overall, this comprehensive review highlights the significant potential of targeting copper metabolism as a promising and effective approach in cancer treatment, while providing valuable insights into the current state of research in this field.Copyright © 2023 Kong and Sun.