铁死亡（Ferroptosis）是一种调控的细胞死亡形式，首次在2012年被定义。铁死亡主要涉及到铁驱动的细胞脂质过氧化损伤。该过程受到铁稳态、氧化还原平衡、脂质代谢、谷胱甘肽代谢和各种疾病信号通路的调控。铁是调节女性生理功能和卵巢肿瘤发展的关键矿物元素之一。铁死亡在卵巢疾病中存在一些潜在的危险和优势。一些学者已经表明卵泡颗粒细胞（GC）的铁死亡促进了卵巢功能障碍和多囊卵巢综合征（PCOS）的发展。有趣的是，抗药性卵巢癌细胞对铁死亡非常敏感，提示通过药物对铁死亡进行正负调节在治疗良性卵巢疾病和卵巢癌方面具有巨大潜力。本文旨在评估铁死亡的发生机制以及控制铁死亡的因素。此外，我们总结了铁死亡在卵巢疾病中的预测、诊断和靶向治疗方面的应用。同时，我们还评估了铁死亡在卵巢疾病中不同现象的特点。其目的是为女性生殖疾病的研究和预防提供新的方向。版权所有 © 2023 Yao, Wang, Jiang, Guo and Li.

Ferroptosis, a form of regulated cell death, was first defined in 2012. Ferroptosis mainly involves iron-driven lipid peroxidation damage of cells. This process is regulated by iron homeostasis, redox balance, lipid metabolism, glutathione metabolism, and various disease signaling pathways. Iron is one of the key mineral elements that regulate the physiological function of women and the development of ovarian tumors. Occurrence of Ferroptosis has some hidden dangers and advantages in ovary diseases. Some scholars have shown that ferroptosis of ovarian granulosa cells (GC) promotes the development of ovarian dysfunction and polycystic ovary syndrome (PCOS). Interestingly, drug-resistant ovarian cancer cells are very sensitive to ferroptosis, suggesting that pharmacological positive and negative regulation of ferroptosis has great potential in the treatment of benign ovarian diseases and ovarian cancer. This article aimed to assess how ferroptosis occurs and the factors controlling ferroptosis. Moreover, we summarize how ferroptosis can be used to predict, diagnose and target treatment ovary disease. Meanwhile, we also evaluated the different phenomena of Ferroptosis in ovarian diseases. It aims to provide new directions for the research and prevention of female reproductive diseases.Copyright © 2023 Yao, Wang, Jiang, Guo and Li.