近年来,关于一种天然黄酮类化合物—芹菜素的生物效应、代谢、稳定性和输送系统的研究取得了显著进展:挑战与展望。
Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectives.
发表日期:2023
作者:
Peng Chen, Fuchao Chen, ZhiLei Guo, Jiexin Lei, Benhong Zhou
来源:
Food & Function
摘要:
芹菜素是一种广泛存在于膳食植物食物中的生物类黄酮化合物,具有保护免疫、心血管和神经退行性疾病以及癌症的生物活性。因此,芹菜素被广泛用于食品和药物中,人们越来越关注开发新的芹菜素传递系统。本综述重点介绍芹菜素的生物效应、代谢、稳定性和生物活性。此外,我们总结了芹菜素传递方面的进展,为其在食品和药物中的广泛应用提供了参考。芹菜素的更好稳定性可以增强其消化吸收并提供健康益处。构建芹菜素的传递系统(如乳液、纳米结构脂负载体、水凝胶和脂质体)是改善其生物利用度的有效策略,但需要进行更多的动物和细胞实验来验证这些发现。开发芹菜素传递系统以用于食品商业化仍然具有挑战性,需要进一步研究来促进其深入发展和利用。版权所有 © 2023 Chen, Chen, Guo, Lei and Zhou.
Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and possesses biological activities that protect against immune, cardiovascular, and neurodegenerative diseases and cancer. Therefore, apigenin is widely used in food and medicine, and increasing attention has been drawn to developing new delivery systems for apigenin. This review highlights the biological effects, metabolism, stability, and bioactivity of apigenin. In addition, we summarized advancements in the delivery of apigenin, which provides some references for its widespread use in food and medicine. Better stability of apigenin may enhance digestion and absorption and provide health benefits. Constructing delivery systems (such as emulsions, nanostructured lipid carriers, hydrogels, and liposomes) for apigenin is an effective strategy to improve its bioavailability, but more animal and cell experiments are needed to verify these findings. Developing apigenin delivery systems for food commercialization is still challenging, and further research is needed to promote their in-depth development and utilization.Copyright © 2023 Chen, Chen, Guo, Lei and Zhou.