背景：癌症仍然是全球面临的重大健康挑战和主要死因。在水果和蔬菜中发现的黄酮类化合物因其潜在抗癌特性而备受关注。丰富的黄酮类化合物菲司替尼存在于草莓、苹果、洋葱和其他植物源中，已成为癌症预防的有希望候选药物。流行病学研究发现富含这些食物的饮食与较低的癌症风险相关，引发了对菲司替尼疗效的广泛研究。目的：本综述旨在全面探讨菲司替尼在抗癌性能方面的分子机制，并研究其与其他抗癌药物的可能协同效应。此外，综述还对菲司替尼在不同癌症中的治疗和预防效果进行验证。方法：对与菲司替尼的抗癌性能相关的研究文章、临床试验和综述进行系统分析。检索权威数据库，并批判性评估选定研究以提取菲司替尼的作用机制和其与其他抗癌药物的相互作用的重要信息。结果：临床前试验表明，菲司替尼通过细胞周期改变、诱导细胞凋亡和激活自噬信号通路等机制抑制癌细胞生长。此外，菲司替尼能降低活性氧水平，有助于其整体抗癌潜力。其与其他抗癌药物的协同效应研究表明了组合疗法的潜力。结论：作为一种富含于水果和蔬菜中的生物活性黄酮类化合物，菲司替尼通过多重作用机制展现出有前景的抗癌性能。临床前试验为进一步进行人体临床试验奠定了基础。深入了解菲司替尼的分子机制对于开发新颖、安全和有效的癌症预防和治疗策略至关重要。其与其他抗癌药物的潜在协同效应为组合疗法打开了新的途径，增强了癌症管理方法和全球健康成果。作者基于Creative Commons Attribution许可证发布了本开放获取文章，允许在原文引用正确的情况下进行无限制使用、分发和复制（ https://creativecommons.org/licenses/by/4.0/ ）。

Background  Cancer remains a critical global health challenge and a leading cause of mortality. Flavonoids found in fruits and vegetables have gained attention for their potential anti-cancer properties. Fisetin, abundantly present in strawberries, apples, onions, and other plant sources, has emerged as a promising candidate for cancer prevention. Epidemiological studies linking a diet rich in these foods to lower cancer risk have sparked extensive research on fisetin's efficacy. Objective  This review aims to comprehensively explore the molecular mechanisms of fisetin's anticancer properties and investigate its potential synergistic effects with other anticancer drugs. Furthermore, the review examines the therapeutic and preventive effects of fisetin against various cancers. Methods  A systematic analysis of the available scientific literature was conducted, including research articles, clinical trials, and review papers related to fisetin's anticancer properties. Reputable databases were searched, and selected studies were critically evaluated to extract essential information on fisetin's mechanisms of action and its interactions with other anticancer drugs. Results  Preclinical trials have demonstrated that fisetin inhibits cancer cell growth through mechanisms such as cell cycle alteration, induction of apoptosis, and activation of the autophagy signaling pathway. Additionally, fisetin reduces reactive oxygen species levels, contributing to its overall anticancer potential. Investigation of its synergistic effects with other anticancer drugs suggests potential for combination therapies. Conclusion  Fisetin, a bioactive flavonoid abundant in fruits and vegetables, exhibits promising anticancer properties through multiple mechanisms of action. Preclinical trials provide a foundation for further exploration in human clinical trials. Understanding fisetin's molecular mechanisms is vital for developing novel, safe, and effective cancer prevention and treatment strategies. The potential synergy with other anticancer drugs opens new avenues for combination therapies, enhancing cancer management approaches and global health outcomes.The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ).