细胞死亡是发生在生物体中的自然生物过程。自1963年以来，广泛的研究已经揭示了细胞死亡的发生、进展和最终结果。根据不同细胞表型，细胞死亡被分类为不同类型，包括凋亡，火凤凰，冰死，自噬，铁死，铜死等等。然而，无论细胞死亡形式如何，我们最终期望的是异常细胞（例如肿瘤细胞）的消失，而正常细胞幸存。因此，研究细胞死亡的细节，包括死亡触发器，强调调节因子和执行者，是至关重要的。虽然在理解细胞死亡的分子通路方面取得了重要进展，但由于细胞中复杂的调节网络，许多方面仍然不清楚。其中，磷脂酰肌醇3激酶（PI3K）/蛋白激酶B（AKT）通路被发现是细胞死亡过程的一个关键调节因子。作为一种原癌基因，AKT因其在调节多种细胞功能（包括代谢、免疫、增殖、生存、转录和蛋白质合成等）中的作用，已经成为医学界的关注重点。在本文中，我们探讨了PI3K/AKT通路与细胞死亡之间的联系，旨在加深对这一过程机制的理解。这样的知识可能为寻找适合药物干预的合适靶点等更有效的疾病治疗方法的开发铺平道路。©2023 Wiley Periodicals LLC.

Cell death is a natural biological process that occurs in living organisms. Since 1963, extensive research has shed light on the occurrence, progress, and final outcome of cell death. According to different cell phenotypes, it is classified into different types, including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis, cuproptosis, and so on. However, regardless of the form of cell death, what we ultimately expect is the disappearance of abnormal cells, such as tumor cells, while normal cells survive. As a result, it is vital to investigate the details of cell death, including death triggers, potent regulators, and executioners. Although significant progress has been made in understanding molecular pathways of cell death, many aspects remain unclear because of the complex regulatory networks in cells. Among them, the phosphoinositide-3-kinase (PI3K)/protein kinase B(AKT) pathway is discovered to be a crucial regulator of the cell death process. AKT, as a proto-oncogene, has become a major focus of attention in the medical community due to its role in regulating a multiplicity of cellular functions counting metabolism, immunity, proliferation, survival, transcription, and protein synthesis. Here, we explored the connection between the PI3K/AKT pathway and cell death, aiming to enhance our comprehension of the mechanism underlying this process. Such knowledge may pave the way for the subsequent development of more effective disease treatments, such as finding suitable targets for drug intervention.© 2023 Wiley Periodicals LLC.