TRPS1是乳腺癌（BC）的一种新型、敏感的标记物。唾液腺和乳腺都属于外分泌腺，因此它们的肿瘤可能具有相似的形态和免疫表型。在唾液腺型乳腺癌中，TRPS1在分泌性癌（SCs）中呈阳性，但在腺泡细胞癌（AciCCs）和大部分腺样囊性癌（AdCCs）中呈阴性。少数唾液导管癌（SDCs）呈阳性。在这里，我们调查了唾液腺肿瘤（SGTs）中TRPS1的免疫组化表达。回顾性检索得到了110例SGT（97例原发性和13例转移性）。TRPS1免疫组织化学检测的评分为阴性、低阳性、中度阳性或强阳性。TRPS1在78%（14/18）的多形性腺瘤（PA）中表达，但在所有华尔甜肿瘤中是阴性/低阳性（6/6，100%）。在基底细胞腺瘤（BCA）中，TRPS1在间质细胞中表达中度到强阳性（13/14，92%），而管腔或基底细胞表达低。恶性SGT中TRPS1的表达不同，中度到强阳性的免疫组织化学染色在所有腺样囊性癌（15/15，100%）、基底细胞腺癌（5/5，100%）、导管内癌（3/3，100%）、多形性腺癌（8/9，89%）和唾液导管癌（7/8，89%）中观察到，而在分泌性癌（3/3，100%）、腺泡细胞癌（8/9，89%）和黏液表皮样癌（3/3，50%）中观察到阴性/低阳性表达。此外，肺部、淋巴结和软组织的转移性SGT中观察到强阳性和中度TRPS1表达。总体而言，TRPS1在PA以及恶性和转移性SGT中强烈表达。此外，TRPS1在BCA的间质细胞中呈阳性，但在导管和基底细胞中呈阴性或低阳性。 © 作者（们）2023年。由牛津大学出版社代表美国临床病理学协会出版。保留所有权利。有关许可，请发送电子邮件至: journals.permissions@oup.com。

TRPS1 is a new, sensitive marker for breast carcinoma (BC). Salivary glands and breasts are both exocrine glands; thus, their tumors may share similar morphology and immunophenotype. Among salivary gland-type BC, TRPS1 is reported to be positive in secretory carcinomas (SCs) but negative in acinic cell carcinomas (AciCCs) and most adenoid cystic carcinomas (AdCCs). A subset of salivary duct carcinomas (SDCs) is positive for TRPS1. Herein, we investigate TRPS1 immunohistochemical expression in salivary gland tumors (SGTs).A retrospective search yielded 110 SGTs (97 primary and 13 metastatic). TRPS1 immunohistochemistry was scored as negative, low positive, intermediate positive, or strongly positive.TRPS1 was expressed in 78% (14/18) of pleomorphic adenoma (PA) cases but negative/low positive in all Warthin tumors (6/6 [100%]). In basal cell adenoma (BCA), TRPS1 expression was intermediate to strong (13/14 [92%]) in the stromal cells, whereas ductal or basal cells showed low expression. TRPS1 expression varied in malignant SGTs, with intermediate to strong staining in 100% (15/15) of AdCCs, 100% (5/5) of basal cell adenocarcinoma, 100% (3/3) of intraductal carcinoma, 89% (8/9) of polymorphous adenocarcinoma, and 89% (7/8) of SDCs; negative/low positive expression was observed in 100% (3/3) of SCs, 89% (8/9) of AciCCs, and 50% (3/3) of mucoepidermoid carcinomas. In addition, strong and intermediate TRPS1 expression was observed in metastatic SGT to the lungs, lymph nodes, and soft tissue.Overall, TRPS1 is strongly expressed in PA as well as malignant and metastatic SGT. In addition, TRPS1 is positive in stromal cells of BCA but negative or low positive in ductal and basal cells.© The Author(s) 2023. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.