尽管儿童癌症放疗后对生活质量产生了影响，但很少有报告描述了儿童癌症放疗后晚期眼毒性的风险。《临床中的儿童正常组织效应（PENTEC）眼科工作组》旨在量化选定晚期不良眼睛效应与放射剂量的关系。在这里，我们报告了接受颅脑放疗的儿童癌症幸存者的视网膜病变、视神经病变和白内障的结果。使用PubMed、MEDLINE和Cochrane图书馆数据库进行系统的文献搜索，涵盖了1980年至2021年发表的与儿童癌症、放疗和眼部指标（包括干眼症、角膜炎/角膜损伤、结膜损伤、白内障、视网膜病变和视神经病变）有关的同行评审研究。这次初始搜索得到了2947份参考文献的摘要，其中269份被选为可能具有有用结局和放疗数据的文献。根据数据，利用治疗和结局数据生成了正常组织并发症概率模型。我们找到了足够的放疗数据，以生成以下三个指标的正常组织并发症概率模型：视网膜病变、视神经病变和白内障形成。根据有限的数据，视网膜病变的模型表明，在42 Gy和62 Gy时，毒性风险分别为5%和50%。视神经病变的模型表明，在57 Gy和64 Gy时，毒性风险分别为5%和50%。可获得更充分的数据来评估白内障的风险，区分了患者自述与眼科医生诊断的白内障。模型表明，在12 Gy和>40 Gy时，自述的白内障的风险分别为5%和50%，眼科医生诊断的白内障的毒性风险为50 Gy（对仅接受化疗的患者，长期风险在0 Gy时>5%）。眼睛的放射剂量效应在儿科人群中研究不足。根据有限的已发表数据，这次PENTEC全面回顾确定了放疗剂量与视网膜病变、视神经病变和白内障形成之间的关系。版权所有© 2023 Elsevier Inc.。保留所有权利。

Few reports describe the risks of late ocular toxicities after radiation therapy (RT) for childhood cancers despite their effect on quality of life. The Pediatric Normal Tissue Effects in the Clinic (PENTEC) ocular task force aims to quantify the radiation dose dependence of select late ocular adverse effects. Here, we report results concerning retinopathy, optic neuropathy, and cataract in childhood cancer survivors who received cranial RT.A systematic literature search was performed using the PubMed, MEDLINE, and Cochrane Library databases for peer-reviewed studies published from 1980 to 2021 related to childhood cancer, RT, and ocular endpoints including dry eye, keratitis/corneal injury, conjunctival injury, cataract, retinopathy, and optic neuropathy. This initial search yielded abstracts for 2947 references, 269 of which were selected as potentially having useful outcomes and RT data. Data permitting, treatment and outcome data were used to generate normal tissue complication probability models.We identified sufficient RT data to generate normal tissue complication probability models for 3 endpoints: retinopathy, optic neuropathy, and cataract formation. Based on limited data, the model for development of retinopathy suggests 5% and 50% risk of toxicity at 42 and 62 Gy, respectively. The model for development of optic neuropathy suggests 5% and 50% risk of toxicity at 57 and 64 Gy, respectively. More extensive data were available to evaluate the risk of cataract, separated into self-reported versus ophthalmologist-diagnosed cataract. The models suggest 5% and 50% risk of self-reported cataract at 12 and >40 Gy, respectively, and 50% risk of ophthalmologist-diagnosed cataract at 9 Gy (>5% long-term risk at 0 Gy in patients treated with chemotherapy only).Radiation dose effects in the eye are inadequately studied in the pediatric population. Based on limited published data, this PENTEC comprehensive review establishes relationships between RT dose and subsequent risks of retinopathy, optic neuropathy, and cataract formation.Copyright © 2023 Elsevier Inc. All rights reserved.