本研究旨在确定综合老年评估（Comprehensive Geriatric Assessment，CGA）中包括的哪些性能评估工具对于初始评估和治疗过程中被诊断为弥漫性大B细胞淋巴瘤（Diffuse Large B-Cell Lymphoma，DLBCL）的老年患者的功能方法最为敏感。我们在三级医院血液学门诊中招募了31名70岁及以上的患者进行初始咨询。我们在基线和治疗期间作为CGA的一部分实施了更新的身体功能评估。根据年龄、老年8项量表（Geriatric 8，G8）、脆弱性、短期身体功能评估（Short Physical Performance Battery，SPPB）以及通过握力测量的肌肉萎缩进行比较样本的基线特征。通过握力测量（Hand Grip Strength，HGS）、步态速度（Gait Speed，GS）和SPPB来监测治疗期间的功能变化。平均年龄为79.0岁（5.5岁），样本中51.6％的患者脆弱；65.5％接受标准化疗，35.5％接受剂量减弱的治疗方案。在样本根据脆弱性、肌肉萎缩和SPPB分层比较时，CGA包括的所有评估工具在基线时发现了功能差异，但根据G8分数和年龄并无差异。只有SPPB在基线时能够检测到根据年龄分层的功能差异。GS是唯一在治疗期间识别到临床显著的功能变化的评分。总而言之，HGS和SPPB是依据功能方法进行初始血液学评估的适当评分，GS是在DLBCL老年患者治疗期间检测功能恶化的一种有前景的选择。© 2023年。作者（或授权机构）独家授权Springer-Verlag GmbH Germany，属于Springer Nature出版社。

This study aimed to determine which performance assessment tools included in Comprehensive Geriatric Assessment (CGA) are the most sensitive for the functional approach in the initial evaluation and during the therapy of old adults diagnosed with Diffuse Large B-Cell Lymphoma (DLBCL). We prospectively recruited 31 patients aged 70 years or older presenting for an initial consultation in the Hematology Clinic of a tertiary hospital. We implemented an updated physical performance evaluation as part of CGA at baseline and during treatment. Baseline characteristics of the sample were compared according to age, Geriatric 8 (G8), frailty, Short Physical Performance Battery (SPPB), and sarcopenia measured by hand grip strength (HGS). Functional changes were monitored during the treatment period using HGS, gait speed (GS) and SPPB. The mean age was 79.0 (5.5) years and 51.6% of the sample was frail; 65,5% were treated with standard chemotherapy and 35,5% with a therapeutic regimen with attenuated doses. All the assessment tools included in CGA found functional differences at baseline when the sample was stratified and compared according to frailty, sarcopenia, and SPPB, but not according to G8 score and age. Only SPPB was able to detect functional differences between groups stratified by age at baseline. GS was the only score that identified clinically significant functional changes during the treatment. In conclusion, HGS and SPPB are appropriate performance scores to complete the functional approach in the initial hematologic evaluation, and GS is a promising option to detect functional decline during therapy in old adults with DLBCL.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.