肝纤维化是由持续性肝损伤引起的创伤愈合反应，并可能发展为肝硬化甚至肝癌，若没有干预措施。根据当前的认识，肝纤维化是可逆的。因此，探索与肝抗纤维化相关的基因靶点或生物标志物具有重要意义。胰岛素样生长因子1（IGF1）及其受体（IGF1R）主要在肝组织中表达，并在肝功能中发挥关键作用。本综述总结了IGF1/IGF1R及其信号系统在肝纤维化中的作用，并根据对肝或其他器官纤维化的研究阐明了DNA损伤修复、细胞衰老、脂质代谢和氧化应激等可能涉及的潜在机制。特别是详述了IGF1和IGF1R在DNA损伤修复中的作用，包括膜定位和核定位的IGF1R。此外，对于肝抗纤维化的每一潜在机制，都包括通过IGF1和IGF1R介导的信号通路以及在不同条件下肝细胞中作用的细胞种类。本综述中的数据将为研究IGF1/IGF1R在多种因素诱导的肝纤维化中的作用提供支持，并为肝纤维化的研究聚焦于不同种类肝细胞之间的相互作用提供基础。版权所有 © 2023. Elsevier B.V. 发布。

Liver fibrosis is a wound-healing response due to persistent liver damage and it may progress to cirrhosis and even liver cancer if no intervention is given. In the current cognition, liver fibrosis is reversible. So, it is of great significance to explore the related gene targets or biomarker for anti-fibrosis of liver. Insulin like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) are mainly expressed in the liver tissues and play critical roles in the liver function. The present review summarized the role of IGF1/IGF1R and its signaling system in liver fibrosis and illustrated the potential mechanisms including DNA damage repair, cell senescence, lipid metabolism and oxidative stress that may be involved in this process according to the studies on the fibrosis of liver or other organs. In particular, the roles of IGF1 and IGF1R in DNA damage repair were elaborated, including membrane-localized and nucleus-localized IGF1R. In addition, for each of the potential mechanism in anti-fibrosis of liver, the signaling pathways of the IGF1/IGF1R mediated and the cell species in liver acted by IGF1 and IGF1R under different conditions were included. The data in this review will support for the study about the effect of IGF1/IGF1R on liver fibrosis induced by various factors, meanwhile, provide a basis for the study of liver fibrosis to focus on the communications between the different kinds of liver cells.Copyright © 2023. Published by Elsevier B.V.