逆转炎症过程-肿瘤坏死因子-α抑制剂的25年研究。
Reversing the Inflammatory Process-25 Years of Tumor Necrosis Factor-α Inhibitors.
发表日期：2023 Jul 31
作者：
Katharina N Muth, Juergen Rech, Florian O Losch, André Hoerning
来源：
Arthritis & Rheumatology
摘要：
免疫介导的炎症性疾病，如风湿关节炎、银屑病性关节炎、周围和/或轴型脊柱关节炎、克罗恩病和溃疡性结肠炎，表现为免疫系统分子和细胞变化。由于这些疾病的全身性特点，肝脏或心血管系统通常受炎症过程影响。肿瘤坏死因子-α抑制剂疗法通过降低促炎信号通路的活化，恢复细胞平衡，缓解慢性炎症过程，减轻疼痛和组织损伤等临床后果。
Immune-mediated inflammatory diseases, such as rheumatoid arthritis, psoriatic arthritis, peripheral and/or axial spondyloarthritis, Crohn's disease, and ulcerative colitis, are characterized by molecular and cellular changes in the immune system. Due to the systemic nature of these diseases, organs such as the liver or cardiovascular system are often affected by the inflammatory process. Tumor necrosis factor-α inhibitor therapy reduces the activation of pro-inflammatory signaling cascades, mitigates the chronic inflammatory process by restoring cellular balance, and alleviates clinical consequences, such as pain and tissue damage.