研究动态
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罗汉参(Rhodiola rosea L.)中的酚类化合物作为潜在的慢性疾病替代治疗方法。

Phenolic Compounds of Rhodiola rosea L. as the Potential Alternative Therapy in the Treatment of Chronic Diseases.

发表日期:2023 Jul 31
作者: Jurga Bernatoniene, Valdas Jakstas, Dalia M Kopustinskiene
来源: PHYSICAL THERAPY & REHABILITATION JOURNAL

摘要:

在北欧、北美和西伯利亚广泛分布的红景天(Crassulaceae)的根和根茎,自古以来就被用于缓解压力、疲劳和心理和身体失调。苯丙烯类酚类化合物:花青苷rosavin,rosarin和rosin,酪醇糖苷salidroside和酪醇,是红景天生物学作用的原因,具有抗氧化、免疫调节、抗衰老和抗疲劳活性。红景天提取物配方被用作增强精神和认知功能,以及在应对压力时保护中枢神经系统和心脏的替代疗法。最近的研究表明,红景天可以用于治疗糖尿病、癌症以及包括阿尔茨海默病和帕金森病在内的多种心血管和神经系统疾病。本文综述了红景天提取物的有益效果、其关键活性成分以及它们在慢性疾病治疗中的可能应用。红景天代表了一种出色的天然疗法,用于处理包括疲劳和虚弱感在内的性能下降情况,特别是在慢性疾病背景下。鉴于线粒体在细胞能量代谢中的重要性及其对活性氧的易损性,未来的研究应优先调查红景天主要活性酚类化合物对线粒体的潜在影响,从而针对细胞能量供应并对抗与氧化应激相关的影响。
The roots and rhizomes of Rhodiola rosea L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, and rosin, tyrosol glucoside salidroside, and tyrosol, are responsible for the biological action of R. rosea, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. R. rosea extract formulations are used as alternative remedies to enhance mental and cognitive functions and protect the central nervous system and heart during stress. Recent studies indicate that R. rosea may be used to treat diabetes, cancer, and a variety of cardiovascular and neurological disorders such as Alzheimer's and Parkinson's diseases. This paper reviews the beneficial effects of the extract of R. rosea, its key active components, and their possible use in the treatment of chronic diseases. R. rosea represents an excellent natural remedy to address situations involving decreased performance, such as fatigue and a sense of weakness, particularly in the context of chronic diseases. Given the significance of mitochondria in cellular energy metabolism and their vulnerability to reactive oxygen species, future research should prioritize investigating the potential effects of R. rosea main bioactive phenolic compounds on mitochondria, thus targeting cellular energy supply and countering oxidative stress-related effects.