溶磷脂酸（LPA）是一种生物活性磷脂，调节多种细胞生物学功能中的生理和病理过程，包括细胞迁移、凋亡和增殖等。巨噬细胞广泛存在于人体各种组织中，具有多种生理和病理功能。越来越多的证据表明，LPA信号在巨噬细胞的生理功能中发挥重要作用，并加速了由巨噬细胞功能障碍和炎症引起的疾病的发展，如与炎症相关的疾病、癌症、动脉粥样硬化和纤维化等。在本综述中，我们总结了LPA在巨噬细胞中的作用，分析了由LPA引发的多种与巨噬细胞和炎症有关的疾病，并讨论了LPA靶向治疗策略。

Lysophosphatidic acid (LPA) is a bioactive phospholipid that regulates physiological and pathological processes in numerous cell biological functions, including cell migration, apoptosis, and proliferation. Macrophages are found in most human tissues and have multiple physiological and pathological functions. There is growing evidence that LPA signaling plays a significant role in the physiological function of macrophages and accelerates the development of diseases caused by macrophage dysfunction and inflammation, such as inflammation-related diseases, cancer, atherosclerosis, and fibrosis. In this review, we summarize the roles of LPA in macrophages, analyze numerous macrophage- and inflammation-associated diseases triggered by LPA, and discuss LPA-targeting therapeutic strategies.