婆罗洲蒜树,学名Scorodocarpus borneensis (Baill.) Becc. (Olacaceae):在制药、保健品和功能性化妆品行业的潜在应用。
The Garlic Tree of Borneo, Scorodocarpus borneensis (Baill.) Becc. (Olacaceae): Potential Utilization in Pharmaceutical, Nutraceutical, and Functional Cosmetic Industries.
发表日期:2023 Jul 28
作者:
Christophe Wiart, Afsana Amin Shorna, Mohammed Rahmatullah, Veeranoot Nissapatorn, Jaya Seelan Sathya Seelan, Homathevi Rahman, Nor Azizun Rusdi, Nazirah Mustaffa, Layane Elbehairy, Mazdida Sulaiman
来源:
CLINICAL PHARMACOLOGY & THERAPEUTICS
摘要:
婆罗洲镰果木(Scorodocarpus borneensis (Baill.)Becc.)作为东南亚潜在的商业草药植物产品而引起了越来越多的关注。本综述总结了关于S. borneensis的分类学、栖息地、分布、药用、天然产物、药理学、毒理学和制药/保健品/功能化妆品产业中的潜在利用的现有知识。综述中的所有数据均来自于Google Scholar、PubMed、Science Direct、Web of Science、ChemSpider、PubChem以及从1866年至2022年进行的图书馆搜索。已发现了33种天然产物,其中有11种是有机硫化物。种子中的主要有机硫化合物是双-(甲硫基甲基)二硫化物,它能抑制广谱细菌和真菌、T淋巴母细胞白血病细胞和血小板聚集的生长。有机提取物可激发抗微生物、细胞毒性、抗自由基和杀白蚁效果。S. borneensis及其天然产物具有重要且可能申请专利的药理学特性。尤其是种子有潜力用作食品防腐剂、杀菌剂或白蚁杀虫剂的来源。然而,仍需确定急性和慢性毒性、检查体内药理学效应并进行临床研究。
Scorodocarpus borneensis (Baill.) Becc. is attracting increased attention as a potential commercial medicinal plant product in Southeast Asia. This review summarizes the current knowledge on the taxonomy, habitat, distribution, medicinal uses, natural products, pharmacology, toxicology, and potential utilization of S. borneesis in the pharmaceutical/nutraceutical/functional cosmetic industries. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1866 to 2022. A total of 33 natural products have been identified, of which 11 were organosulfur compounds. The main organosulfur compound in the seeds is bis-(methylthiomethyl)disulfide, which inhibited the growth of a broad spectrum of bacteria and fungi, T-lymphoblastic leukemia cells, as well as platelet aggregation. Organic extracts evoked anti-microbial, cytotoxic, anti-free radical, and termiticidal effects. S. borneensis and its natural products have important and potentially patentable pharmacological properties. In particular, the seeds have the potential to be used as a source of food preservatives, antiseptics, or termiticides. However, there is a need to establish acute and chronic toxicity, to examine in vivo pharmacological effects and to perform clinical studies.