精油是复杂的芳香物质混合物，其药理作用包括抗菌、抗氧化、抗癌和抗炎活性已有广泛报道。本研究旨在评估来自厄瓜多尔本地和培育植物的精油的抗念珠菌和皮肤抗炎活性。通过水蒸气蒸馏从Bursera graveolens、Dacryodes peruviana、Mespilodaphne quixos和Melaleuca armillaris中分离精油，并进行了物理和化学特性的表征。通过体外和体内研究分析了其耐受性。抗真菌活性针对念珠菌属（Candida albicans，Candida glabrata和Candida parapsilosis）进行了研究，而抗炎效果则通过小鼠耳水肿模型进行评估。主要化合物分别为柠檬烯、α-苯骈烯、（E）-肉桂酸甲酯和1,8-桉叶油醇。所有精油在皮肤应用方面都表现出高的耐受性，对三株念珠菌的抗真菌活性以及通过减轻肿胀和抗炎因子过度表达来发挥抗炎功效。Dacryodes peruviana精油显示了最高的抗真菌活性。另一方面，Dacryodes peruviana和Melaleuca armillaris显示了最大的抗炎潜力，分别减轻了53.3%和65.25%的肿胀，并抑制了TNF-α、IL-8、IL-17A和IL-23的过度表达。结果表明，这些精油可以作为治疗皮肤念珠菌病和皮肤炎症的替代疗法。

Essential oils are a complex mixture of aromatic substances whose pharmacological actions, including antimicrobial, antioxidant, anticancer, and anti-inflammatory activities, have been widely reported. This study aimed to evaluate the anti-Candida and dermal anti-inflammatory activity of essential oils from native and cultivated Ecuadorian plants. Essential oils from Bursera graveolens, Dacryodes peruviana, Mespilodaphne quixos, and Melaleuca armillaris were isolated by hydrodistillation and were characterized physically and chemically. Its tolerance was analyzed by in vitro and in vivo studies. The antifungal activity was studied against Candida albicans, Candida glabrata, and Candida parapsilosis, whereas the anti-inflammatory effect was evaluated by a mouse ear edema model. The main compounds were limonene, α-phellandrene, (E)-methyl cinnamate, and 1,8-cineole, respectively. All essential oils showed high tolerability for skin application, antifungal activity against the three Candida strains, and anti-inflammatory efficacy by decreasing edema and overexpression of pro-inflammatory cytokines. Dacryodes peruviana essential oil showed the highest antifungal activity. On the other hand, Dacryodes peruviana and Melaleuca armillaris showed the greatest anti-inflammatory potential, decreasing edema by 53.3% and 65.25%, respectively, and inhibiting the overexpression of TNF-α, IL-8, IL-17A, and IL-23. The results suggest that these essential oils could be used as alternative therapies in the treatment of both cutaneous candidiasis and dermal inflammation.