慢性疼痛是癌症治疗过程中长期存在的一种疾病。有报道称，在肿瘤发展期间，白介素（IL）-1参与了炎症反应的过程。IL1R1和IL1R2是细胞因子受体家族中的成员。然而，很少有研究报道与慢性疼痛相关的基因IL1R1在全癌中的作用。本研究通过研究8例腰椎间盘突出（LDP）患者和8名对照组中的差异表达基因，寻找与慢性疼痛相关的基因。然后，使用TCGA数据库对IL1R1进行分析。TCGA的临床生存数据用于分析IL1R1的预后价值。本研究进一步评估了IL1R1与免疫检查点、免疫活化基因、免疫抑制基因、趋化因子和趋化因子受体之间的关系。IL1R1在大多数TCGA肿瘤类型中以不同程度表达，说明其与较好的生存状态相关。IL1R1的表达与T细胞浸润、免疫检查点、免疫活化基因、免疫抑制基因、趋化因子和趋化因子受体密切相关。结果表明，IL1R1是一种潜在的癌症生物标志物。与其他免疫检查点协调，IL1R1可以调节免疫微环境，可用于开发新的靶向药物免疫治疗。

Chronic pain is a disease that existed during cancer treatment for a long time. It has been reported that interleukin (IL)-1 is involved in the inflammatory response during tumor development. IL1R1 and IL1R2 are members of the IL-1 receptor family of cytokine receptors. However, few studies have reported the role of chronic pain-related genes, IL1R1, in pan-cancer. In this study, 8 lumbar disc prolapse (LDP) patients and 8 controls with differentially expressed genes were investigated to find chronic pain-related genes. Then, IL1R1 was analyzed using the TCGA database. The clinical survival data from TCGA were used to analyze the prognostic value of IL1R1. This study further evaluated the relationship between IL1R1 and immune checkpoints, immune-activating genes, immunosuppressive genes, chemokines, and chemokine receptors. IL1R1 was expressed in varying degrees in most TCGA tumor types, indicating a better survival status. The expression of IL1R1 is closely related to T cell infiltration, immune checkpoints, immune-activating genes, immunosuppressive genes, chemokines, and chemokine receptors. The results show that IL1R1 is a kind of potential cancer biomarker. Coordination with other immune checkpoints IL1R1k may adjust the immune microenvironment, immunotherapy can be applied to the development of new targeted drugs.