本研究旨在观察家庭积极行为支持（PBS）护理对恶性肿瘤（MT）患儿CD3+、CD4+、CD4+/CD8+水平和生活质量（QL）的影响。为此，从2021年2月至2022年11月，选择了96名来访郴州市第一人民医院的MT患儿。该医院于2022年1月开始进行家庭PBS护理。根据儿童护理方法的不同，将其分为控制组（C组）和观察组（O组），每组各48例。C组接受常规护理，观察组在C组基础上进行家庭PBS护理。比较CD3+、CD4+、CD4+/CD8+水平和QL评分。结果显示，干预后，两组儿童的CD3+、CD4+、CD4+/CD8+水平、疼痛和伤害、恶心、手术期间焦虑、治疗焦虑、焦虑、外貌自我感知、沟通问题和总分均较干预前有所改善（P<0.05）。干预后，观察组的CD3+、CD4+、CD4+/CD8+水平、焦虑、紧张和认知问题、总分均显著高于C组（P<0.05）。研究结论：将家庭PBS护理应用于MT患儿可以提高CD3+、CD4+、CD4+/CD8+水平，改善儿童的免疫系统功能。它可以改善儿童在手术过程中的焦虑、情绪和认知问题。同时，这种实践还可以帮助儿童增加食欲和体重，从而促进其生活质量。

This study was to observe the effect of family-positive behavior support (PBS) nursing on the level of CD3+, CD4+, CD4+/CD8+ and quality of life (QL) of children with malignant tumor (MT). For this purpose, 96 children with MT who visited the First People's Hospital of Chenzhou City from February 2021 to November 2022 were selected. The hospital carried out family PBS nursing in January 2022. According to the differences in the nursing methods of children, they were divided into a control group (Group C) and an observation group (Group O) with 48 cases each. Group C took routine nursing. The observation group carried out family PBS nursing based on Group C. The CD3+, CD4+, and CD4+/CD8+ levels and QL scores were compared. Results showed that after the intervention, the levels of CD3+, CD4+, CD4+/CD8+, pain and injury, nausea, anxiety during operation, treatment anxiety, anxiety, self-perception of appearance, communication problems and total scores of both groups of children were better than those before the intervention (P<0.05). After the intervention, the levels of CD3+, CD4+, CD4+/CD8+, anxiety, anxiety, cognitive problems and total scores in the observation group were significantly higher than those in Group C (P<0.05). It was concluded that family PBS nursing applied to children with MT can improve the level of CD3+, CD4+, and CD4+/CD8+. The immune system function of children was improved. It improved the anxiety, anxiety and cognitive problems of children in the operation process. At the same time, this practice can help children increase their appetite and weight, and thus promote their quality of life of children.