固体肿瘤和转移瘤的肿瘤微环境中的巨噬细胞是异质性群体，对肿瘤发生的不同阶段起到了贡献。肿瘤相关巨噬细胞（TAMs）可以从循环源的单核细胞或组织驻留巨噬细胞（TRMs）派生而来。在健康状态下，TRMs可以在大多数组织中分布，协调关键的稳态和修复功能。虽然TRM在肿瘤的发生和进展中的特定功能尚不清楚，但最近的研究表明，在小鼠和人类癌症中，TRM是TAM的重要来源，其基因签名与其正常的器官特异性TRM相近。本综述旨在突出最近对TRM作为重要的TAM亚群的作用的系统理解，并探讨这种巨噬细胞群体如何被用于治疗靶向策略的机会。 版权所有 © 2023 作者。由Elsevier Ltd.发表。保留所有权利。

Macrophages within the tumor microenvironment of solid tumors and metastasis are heterogeneous populations, which contribute to diverse steps of tumorigenesis. Tumor-associated macrophages (TAMs) can either derive from circulation-derived monocytes or tissue-resident macrophages (TRMs). In health, TRMs populate the majority of tissues, orchestrating critical homeostatic and reparative functions. While TRM-specific functions in tumor initiation and progression remain unclear, recent studies have revealed that TRMs are a significant source of TAMs in both mouse and human cancers, where they closely resemble gene signatures of their normal, organ-specific TRM counterparts. In this review, we highlight recent advances toward systematically understanding the role of TRMs as an important TAM subset and opportunities how this macrophage population could be exploited for therapeutical targeting strategies.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.