正常妇女手术后保留良好的康复体现，可防止恶性肿瘤发展。本研究旨在比较正常和负常规组织切除后患者的局部复发率，评估高剂量放射治疗对正常切缘的有效性。我们回顾性评估了2013年至2019年之间接受辅助放射治疗的550名浸润性乳腺癌保乳手术患者。对于正常切缘，肿瘤床的等效剂量在65.81至66.25 Gy之间；对于负常规切缘，等效剂量在59.31至61.81 Gy之间。我们分析了正常和负常规切缘组之间局部复发的差异。在中位随访58个月后，正常切缘组（n = 55）的局部复发率为7.3％，而负常规切缘组（n = 495）的局部复发率为2.4％。整个队列中，正常切缘与较高的局部复发率相关，但差异无统计学意义（p = 0.062）。在年龄低于60岁的患者中，与负常规切缘相比，正常切缘患者的5年局部复发率明显较低（89.16％ vs. 97.57％，p = 0.005）。相反，在年龄≥60岁的患者中，正常切缘与负常规切缘的5年局部复发率之间没有显著差异（分别为100.00％和94.38％，p = 0.426）。在本研究中，高剂量放射治疗后的老年患者正常切缘与良好的局部控制率无关。需要进一步的前瞻性研究来验证我们的发现。版权所有©2023The Authors。由Elsevier Ltd.出版。保留所有权利。

Positive margins after breast-conserving surgery are associated with poor oncological outcomes and warrant additional surgery. This study aimed to evaluate the effectiveness of high-dose radiation therapy for positive margins by comparing local recurrence between patients with positive and negative margins.We retrospectively evaluated 550 patients treated with adjuvant radiation therapy after breast-conserving surgery for invasive breast cancer between 2013 and 2019. The total equivalent dose in 2 Gy fractions (EQD2) to the tumor bed ranged from 65.81 to 66.25 Gy for positive margins and 59.31-61.81 Gy for negative margins. The differences in local recurrence between the positive and negative margin groups were analyzed.After a median follow-up of 58 months, the crude local recurrence rate was 7.3% in the positive margin group (n = 55) and 2.4% in the negative margin group (n = 495). Positive margins were associated with higher local recurrence without statistical significance in the entire cohort (p = 0.062). Among patients aged <60 years, those with positive margins had a significantly lower 5-year local recurrence-free survival rate than those with negative margins (89.16% vs. 97.57%, respectively; p = 0.005). In contrast, there was no significant difference in the 5-year local recurrence-free survival rate between patients with positive and negative margins among those aged ≥60 years (100.00% vs. 94.38%, respectively; p = 0.426).In this study, positive margins were not associated with poor local control in older patients after a high-dose boosts. Further prospective studies are needed to verify our findings.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.