肿瘤微环境（TME）中的原肿瘤和抗肿瘤网络之间存在复杂的相互作用。在肿瘤发生过程中，恶性细胞与TME的各种细胞之间的通讯对代谢重编程起到了贡献。肿瘤代谢通路的失调在TME中提供了进化上的优势，并增强了肿瘤的进展、侵袭性和转移能力。因此，了解TME内部的这些相互作用对于开发创新的癌症治疗非常重要。细胞外囊泡（EVs）作为携带各种材料（包括microRNA、蛋白质和脂质）的载体，在肿瘤细胞与非肿瘤细胞之间的通讯中起到至关重要的作用。EVs积极参与代谢重编程过程。本综述总结了近期有关肠胃癌TME中不同细胞的EVs参与代谢重编程的研究发现。此外，我们还强调了参与这一组癌症重编程过程的microRNA，并解释了外泌体中的货物所针对的异常肿瘤代谢以及新的潜在治疗方法。 Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

There is a complex interaction between pro-tumoural and anti-tumoural networks in the tumour microenvironment (TME). Throughout tumourigenesis, communication between malignant cells and various cells of the TME contributes to metabolic reprogramming. Tumour Dysregulation of metabolic pathways offer an evolutional advantage in the TME and enhance the tumour progression, invasiveness, and metastasis. Therefore, understanding these interactions within the TME is crucial for the development of innovative cancer treatments. Extracellular vesicles (EVs) serve as carriers of various materials that include microRNAs, proteins, and lipids that play a vital role in the communication between tumour cells and non-tumour cells. EVs are actively involved in the metabolic reprogramming process. This review summarized recent findings regarding the involvement of EVs in the metabolic reprogramming of various cells in the TME of gastrointestinal cancers. Additionally, we highlight identified microRNAs involved in the reprogramming process in this group of cancers and explained the abnormal tumour metabolism targeted by exosomal cargos as well as the novel potential therapeutic approaches.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.