具有卵石氨酸转运蛋白家族成员11 (SLC7A11)（亦称xCT）功能的卵石氨酸转运蛋白家族11（SLC7A11）是通过导入卵石氨酸来促进谷胱甘肽合成和对抗氧化应激引起的细胞死亡，包括铁死亡。此外，SLC7A11在肿瘤发展中起到关键作用。然而，最近的研究揭示了SLC7A11在促进二硫化物应激引发的一种新型调节细胞死亡形式——二硫化物死亡（disulfidptosis）中的意外作用。在本综述中，我们将探讨SLC7A11在调节氧化还原平衡和细胞存活/死亡方面的对立作用，总结关于二硫化物死亡的当前认识，并探索其在疾病治疗中的潜力。对二硫化物死亡的更深入理解将为基本细胞稳态提供新的见解，并促进创新疾病治疗方法的发展。© 2023 Elsevier Ltd. 保留所有权利。

The cystine transporter solute carrier family 7 member 11 (SLC7A11) (also known as xCT) promotes glutathione synthesis and counters oxidative stress-induced cell death, including ferroptosis, by importing cystine. Also, SLC7A11 plays a crucial role in tumor development. However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. In this review, we examine the opposing roles of SLC7A11 in regulating redox homeostasis and cell survival/death, summarize current knowledge on disulfidptosis, and explore its potential in disease treatment. A deeper understanding of disulfidptosis will offer new insights into fundamental cellular homeostasis and facilitate the development of innovative therapies for disease treatment.Copyright © 2023 Elsevier Ltd. All rights reserved.