紫参碱（SIN）是从紫参中提取的生物碱单体，是一种广泛应用于中国治疗类风湿关节炎（RA）和各种肾小球疾病的非甾体类抗炎药物。它具有抗炎、镇痛和抗肿瘤等多种药理作用。作为一种强组胺释放剂，SIN的副作用日益受到关注，例如过敏、胃肠道和循环系统反应。在本报告中，我们首次描述了一位接受SIN口服治疗的原发性膜性肾病（PMN）患者，出现药物诱发的剥脱性表皮坏死（TEN），随后因感染引起的多器官功能衰竭而死亡。本病例报告意在展示SIN被低估的副作用，可能最终导致死亡。© Dustri-Verlag Dr. K. Feistle.

Sinomenine (SIN), the alkaloid monomer extracted from Sinomenium acutum, is a kind of non-steroidal anti-inflammatory drug widely used in China to treat rheumatoid arthritis (RA) and various glomerular diseases. It has various pharmacological effects such as anti-inflammatory, analgesic, and anti-tumor. As a strong histamine-releasing agent, SIN has drawn increasing attention in regards to its side effects such as allergic, gastrointestinal, and circulatory systemic reactions. In this report, we first described a patient with primary membranous nephropathy (PMN) who was treated with oral intake of SIN and developed medicine-induced toxic epidermal necrolysis (TEN) and subsequently died of septic multi-organ failure. The present case report intends to demonstrate the underestimated side effects of SIN that can eventually lead to death.© Dustri-Verlag Dr. K. Feistle.